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RBPJ and SPOP
Number of citations of the paper that reports this interaction (PubMedID
28805822
)
37
Data Source:
BioGRID
(two hybrid)
RBPJ
SPOP
Description
recombination signal binding protein for immunoglobulin kappa J region
speckle type BTB/POZ protein
Image
GO Annotations
Cellular Component
Nuclear Chromatin
MAML1-RBP-Jkappa- ICN1 Complex
Nucleus
Nucleoplasm
Transcription Factor Complex
Nucleolus
Cytoplasm
Transcriptional Repressor Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Cul3-RING Ubiquitin Ligase Complex
Molecular Function
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific DNA Binding
Protein N-terminus Binding
Repressing Transcription Factor Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Somitogenesis
Epithelial To Mesenchymal Transition
Blood Vessel Remodeling
Inflammatory Response To Antigenic Stimulus
Secondary Heart Field Specification
Outflow Tract Morphogenesis
Endocardium Morphogenesis
Aortic Valve Development
Pulmonary Valve Development
Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Cardiac Left Ventricle Morphogenesis
Ventricular Trabecula Myocardium Morphogenesis
Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Humoral Immune Response
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Negative Regulation Of Cell Proliferation
Auditory Receptor Cell Fate Commitment
Epidermal Cell Fate Specification
Positive Regulation Of Gene Expression
Pituitary Gland Development
B Cell Differentiation
Keratinocyte Differentiation
Negative Regulation Of Ossification
Positive Regulation Of BMP Signaling Pathway
Somatic Stem Cell Population Maintenance
Dorsal Aorta Morphogenesis
Atrioventricular Canal Development
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Cell Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Timing Of Cell Differentiation
Sebaceous Gland Development
Hair Follicle Maturation
Positive Regulation Of Cardiac Muscle Cell Proliferation
Ventricular Septum Morphogenesis
Clara Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Fate Commitment
Notch Signaling Involved In Heart Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Blood Vessel Lumenization
Interleukin-4 Secretion
Blood Vessel Endothelial Cell Fate Specification
Negative Regulation Of Cold-induced Thermogenesis
Positive Regulation Of ERBB Signaling Pathway
Positive Regulation Of Ephrin Receptor Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Regulation Of Proteolysis
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Hedgehog 'on' state
Drugs
Diseases
GWAS
Heel bone mineral density (
30598549
)
Medication use (thyroid preparations) (
31015401
)
Rheumatoid arthritis (
24449572
23143596
20453842
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Prostate cancer (
23535732
)
Interacting Genes
28 interacting genes:
APP
CCNF
CIR1
FHL1
GADD45A
GSK3B
HDAC1
HMGB1
HSPB1
KAT2A
KAT2B
MAML1
MED27
NCOR1
NCOR2
NOTCH1
NOTCH2
NOTCH3
NOTCH4
PTF1A
RPS6KA6
SIN3A
SND1
SNW1
SPEN
SPOP
SUFU
TP53
69 interacting genes:
AEN
AMOTL2
AR
BRD2
BRD3
BRD4
BRMS1
CACUL1
CAPRIN1
CBX4
CCNE1
CDK4
CHAF1A
CHD3
CREB5
CTDSPL2
CUL3
DAXX
DDIT3
DHX15
DPPA2
EGLN2
ERF
ERG
FAF1
GATAD2A
GCC1
GCC2
GIT2
GLI2
GLI3
GMEB1
HCST
HMGCS1
INF2
KPNA5
LRCH4
MACROH2A1
MRE11
MYD88
NANOG
NCOA3
NUDCD3
PDX1
PIAS1
PIAS3
RANBP9
RBFOX2
RBPJ
RPRD2
RTN3
RXRB
SETD2
SRRM1
SUMO1
TCOF1
TOPORS
TRAF1
TRAF6
UBE2D1
UBE2D2
UBE2E3
UBE2I
UBE2L3
VPS9D1-AS1
YWHAG
ZBTB16
ZCCHC12
ZMYND8
Entrez ID
3516
8405
HPRD ID
00920
16004
Ensembl ID
ENSG00000168214
ENSG00000121067
Uniprot IDs
Q06330
O43791
PDB IDs
2F8X
3NBN
3V79
6PY8
2CR2
3HQH
3HQI
3HQL
3HQM
3HSV
3HTM
3HU6
3IVB
3IVQ
3IVV
4EOZ
4HS2
4J8Z
4O1V
6F8F
6F8G
6I41
6I5P
6I68
6I7A
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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