IFNGR1 and CANX

Number of citations of the paper that reports this interaction (PubMedID 8136357)
20

Data Source:
HPRD (in vivo)

		IFNGR1	CANX
Description		interferon gamma receptor 1	calnexin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Ribosome Membrane Axon Dendrite Cytoplasm Protein-containing Complex Melanosome Neuronal Cell Body Dendritic Spine Mitochondria-associated ER Membrane Endoplasmic Reticulum Quality Control Compartment Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Active Zone Membrane
	Molecular Function	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding Cytokine Binding	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Apolipoprotein Binding Ionotropic Glutamate Receptor Binding Unfolded Protein Binding
	Biological Process	Microglial Cell Activation Signal Transduction Response To Virus Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Astrocyte Activation Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Tumor Necrosis Factor Secretion	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Aging Protein Secretion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling	Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Interferon gamma-1b	Antihemophilic factor, human recombinant Tenecteplase Calcium Citrate Calcium Phosphate
Diseases		Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Cognitive decline rate in late mild cognitive impairment ( 26252872) Cognitive performance (processing speed) ( 31598132)	Daytime sleep phenotypes ( 27126917) Myeloid white cell count ( 27863252) Resting heart rate ( 24680774) White blood cell count ( 27863252)
Interacting Genes		9 interacting genes: CANX IFNG IFNGR2 JAK1 JAK2 PTPN11 RAC1 SOCS1 STAT1	44 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F8 FAM107A FSHR GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LPA LRP1 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 NUTF2 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR
Entrez ID		3459	821
HPRD ID		00127	00252
Ensembl ID		ENSG00000027697	ENSG00000127022
Uniprot IDs		A0A0S2Z3Y2 A0A2R8Y4U4 P15260	P27824
PDB IDs		1FG9 1FYH 1JRH 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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