IRGM and NOD2

Number of citations of the paper that reports this interaction (PubMedID 25891078)
57

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		IRGM	NOD2
Description		immunity related GTPase M	nucleotide binding oligomerization domain containing 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Phagocytic Vesicle Membrane Cell Projection	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Basolateral Plasma Membrane Vesicle Protein-containing Complex
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding	Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding
	Biological Process	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Defense Response Inflammatory Response Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Destabilization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Regulation Of Protein Complex Assembly Innate Immune Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Autophagy Of Host Cells Involved In Interaction With Symbiont Cellular Response To Virus Positive Regulation Of Autophagosome Maturation	Activation Of MAPK Activity Cytokine Production Involved In Immune Response Cytokine Secretion Involved In Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Defense Response JNK Cascade Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways			NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs
Diseases			Blau syndrome Crohn's disease
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 17554261 17554300 21102463) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 28067908 23128233)	Asthma ( 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464 28067908) Leprosy ( 20018961 27976721 25642632) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		1 interacting genes: NOD2	37 interacting genes: ALPI ANKHD1 ANXA2 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		345611	64127
HPRD ID		19559	05810
Ensembl ID		ENSG00000237693	ENSG00000167207
Uniprot IDs		A1A4Y4	A0A286YF65 Q9HC29
PDB IDs
Enriched GO Terms of Interacting Partners?
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