IDH2 and PYGL

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		IDH2	PYGL
Description		isocitrate dehydrogenase (NADP(+)) 2	glycogen phosphorylase L
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Peroxisome Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity NAD Binding	Purine Nucleobase Binding Protein Binding ATP Binding Glucose Binding Drug Binding Glycogen Phosphorylase Activity AMP Binding Vitamin Binding Pyridoxal Phosphate Binding Bile Acid Binding Identical Protein Binding Linear Malto-oligosaccharide Phosphorylase Activity SHG Alpha-glucan Phosphorylase Activity
	Biological Process	Carbohydrate Metabolic Process Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP Metabolic Process NADP Biosynthetic Process Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Glial Cell Migration Negative Regulation Of Matrix Metallopeptidase Secretion	Glycogen Metabolic Process Glycogen Catabolic Process 5-phosphoribose 1-diphosphate Biosynthetic Process Response To Bacterium Glucose Homeostasis Neutrophil Degranulation Necroptotic Process
Pathways		Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle)	Neutrophil degranulation Glycogen breakdown (glycogenolysis)
Drugs		Isocitric Acid Enasidenib	Pyridoxal Phosphate Adenosine monophosphate CP-526423 1-N-Acetyl-Beta-D-Glucosamine Beta-D-Glucose 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide Alvocidib Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate Dexfosfoserine PSN357 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA Uric Acid
Diseases			Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
GWAS		Cerebrospinal fluid clusterin levels ( 26545630) Pulse pressure ( 27841878 30578418) Urate levels ( 31578528)	Acute lymphoblastic leukemia (childhood) ( 23007406) Blood protein levels ( 30072576 29875488) Psychosis (atypical) ( 24132900)
Interacting Genes		4 interacting genes: FBXO7 GPX1 PYGL SLC2A4	5 interacting genes: BAG1 HSD17B10 HSD3B7 IDH2 PYGB
Entrez ID		3418	5836
HPRD ID		00973	01987
Ensembl ID		ENSG00000182054	ENSG00000100504
Uniprot IDs		B4DSZ6 P48735	P06737
PDB IDs		4JA8 5GIS 5I95 5I96 5SVN 5SVO 6ADI	1EM6 1EXV 1FA9 1FC0 1L5Q 1L5R 1L5S 1L7X 1XOI 2ATI 2QLL 2ZB2 3CEH 3CEJ 3CEM 3DD1 3DDS 3DDW
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?