ICAM4 and ITGA4

Number of citations of the paper that reports this interaction (PubMedID 11435317)
17

Data Source:
HPRD (in vitro)

		ICAM4	ITGA4
Description		intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)	integrin subunit alpha 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Cell Plasma Membrane Focal Adhesion Cell Surface Membrane Growth Cone Protein-containing Complex Integrin Alpha4-beta7 Complex Neuronal Cell Body Extracellular Exosome
	Molecular Function	Integrin Binding	Fibronectin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Protein Antigen Binding
	Biological Process	Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Cell-matrix Adhesion Involved In Ameboidal Cell Migration Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway B Cell Differentiation Extracellular Matrix Organization Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Diapedesis Axonogenesis Involved In Innervation Cellular Response To Cytokine Stimulus Negative Regulation Of Protein Homodimerization Activity Cell-cell Adhesion In Response To Extracellular Stimulus Positive Regulation Of Leukocyte Tethering Or Rolling Cellular Response To Amyloid-beta Positive Regulation Of Vascular Endothelial Cell Proliferation Neuron Projection Extension Clathrin-dependent Extracellular Exosome Endocytosis Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of T Cell Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions RUNX3 Regulates Immune Response and Cell Migration
Drugs			Natalizumab ATL1102 CDP323 R1295 R411 Tinzaparin Vedolizumab
Diseases
GWAS		Blood protein levels ( 30072576 28240269)	Celiac disease ( 22057235 20190752) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 23314186 28193307 25096241 29403010 27863252) Monocyte percentage of white cells ( 27863252) Monocyte-lymphocyte ratio ( 28193307) Multiple sclerosis ( 24076602) Neurofibrillary tangles ( 25188341) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Ulcerative colitis ( 28067908) White blood cell count ( 29403010 21738480) White blood cell count (basophil) ( 29403010) White blood cell count (monocyte) ( 28158719) White blood cell types ( 21738478)
Interacting Genes		10 interacting genes: AKAP8L CREB3 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 NOTCH2NLA RHAG	16 interacting genes: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		3386	3676
HPRD ID		00198	01894
Ensembl ID		ENSG00000105371	ENSG00000115232
Uniprot IDs		Q14773 U5U6P8	P13612
PDB IDs			3V4P 3V4V 4HKC 5C7Z 5FPI
Enriched GO Terms of Interacting Partners?
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