HTR2C and MPDZ

Number of citations of the paper that reports this interaction (PubMedID 9537516)
41

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HTR2C	MPDZ
Description		5-hydroxytryptamine receptor 2C	multiple PDZ domain crumbs cell polarity complex component
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Cytoplasm Bicellular Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Cell Adhesion Viral Process
Pathways		Serotonin receptors G alpha (q) signalling events
Drugs		Tramadol Citalopram Ziprasidone Methysergide Cabergoline Ropinirole Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Minaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Epicept NP-1 Sertindole Mianserin Asenapine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Setiptiline Sarpogrelate Tiapride
Diseases
GWAS			Central corneal thickness ( 29760442) Corneal hysteresis ( 30894546) Corneal structure ( 23291589) Heel bone mineral density ( 30598549 28869591) Refractive astigmatism ( 30306274)
Interacting Genes		8 interacting genes: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1	16 interacting genes: ABCA1 CAMK2A CLDN1 CLDN5 CRHR1 CSPG4 DRD3 F11R HTR2C KIT MTNR1A PLEKHA1 PLEKHA2 RNF5 SYNGAP1 TSC22D2
Entrez ID		3358	8777
HPRD ID		02429	09155
Ensembl ID		ENSG00000147246	ENSG00000107186
Uniprot IDs		K9J958 P28335	O75970
PDB IDs		6BQG 6BQH	2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?
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