HSPD1 and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
3

Data Source:
BioGRID (two hybrid)

		HSPD1	MCPH1
Description		heat shock protein family D (Hsp60) member 1	microcephalin 1
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Peroxisomal Matrix Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Mitochondrial Crista Coated Vesicle Secretory Granule Protein-containing Complex Zymogen Granule Membrane Raft Lipopolysaccharide Receptor Complex Extracellular Exosome	Cell Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	Lipopolysaccharide Binding Protease Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATPase Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Insulin Binding Unfolded Protein Binding Chaperone Binding Modification-dependent Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Response To Hypoxia B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Response To Ischemia Regulation Of Transcription By RNA Polymerase II 'de Novo' Protein Folding Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Response To Activity Viral Process Response To Lipopolysaccharide Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Response To ATP Cellular Response To Heat Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Response To Cocaine Response To Hydrogen Peroxide Positive Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Estrogen Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Positive Regulation Of Inflammatory Response Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Response To Glucocorticoid Protein Maturation Interaction With Symbiont Negative Regulation Of Apoptotic Process In Bone Marrow Cellular Response To Interleukin-7 Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance
Pathways		Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	Condensation of Prophase Chromosomes
Drugs		Copper
Diseases		Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)	Primary microcephaly (MCPH)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 25056061 29483656)	Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		47 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CLEC7A CLU DHFR ERG FAM107A FHIT H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 YWHAG	68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		3329	79648
HPRD ID		00318	06174
Ensembl ID		ENSG00000144381	ENSG00000147316
Uniprot IDs		A0A024R3X4 P10809	Q8NEM0
PDB IDs		4PJ1	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?
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