BIRC5 and TLE3

		BIRC5	TLE3
Description		baculoviral IAP repeat containing 5	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule Midbody Chromosome Passenger Complex	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex
	Molecular Function	Protein Binding Microtubule Binding Ran GTPase Binding Enzyme Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Chaperone Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Chromosome Segregation Sensory Perception Of Sound Positive Regulation Of Cell Proliferation Cytokine-mediated Signaling Pathway Protein-containing Complex Localization Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Cell Division Mitotic Spindle Assembly	Regulation Of Transcription, DNA-templated Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nucleic Acid-templated Transcription Beta-catenin-TCF Complex Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs		Reserpine Berberine LY2181308
Diseases
GWAS		Blood trace element (Se levels) ( 23720494) Periodontitis (Mean PAL) ( 24024966)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033) Pulmonary function ( 23932459) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		25 interacting genes: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CDCA8 CDK1 CDK4 DIABLO EVI5 FBXL7 H3-4 H3C14 HSP90AA1 INCENP KCNJ6 RAN RASA1 TLE3 XIAP XPO1	19 interacting genes: APP BIRC5 BMP3 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP NDRG1 NOTCH1 PIN1 RPL4 SIX3 SRP14 TAOK2 TCF7L2 XIAP
Entrez ID		332	7090
HPRD ID		04520	02558
Ensembl ID		ENSG00000089685	ENSG00000140332
Uniprot IDs		A0A0B4J1S3 H3BLT4 O15392	B3KUA2 F5H7D6 H0YL70 Q04726 Q6PRX3
PDB IDs		1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N 6SHO
Enriched GO Terms of Interacting Partners?
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