HSPB1 and YWHAE

Number of citations of the paper that reports this interaction (PubMedID 25277244)
18

Data Source:
BioGRID (two hybrid)

		HSPB1	YWHAE
Description		heat shock protein family B (small) member 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
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GO Annotations	Cellular Component	Proteasome Complex Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Extracellular Exosome Axon Cytoplasm	Cell Nucleus Cytoplasm Mitochondrion Cytosol Kinesin Complex Plasma Membrane Focal Adhesion Membrane Melanosome Extracellular Exosome Central Region Of Growth Cone Glutamatergic Synapse
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Binding Involved In Protein Folding	RNA Binding Calcium Channel Regulator Activity Protein Binding Potassium Channel Regulator Activity Enzyme Binding Protein Domain Specific Binding MHC Class II Protein Complex Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Ion Channel Binding Cadherin Binding Protein Heterodimerization Activity Phosphoserine Residue Binding Phosphoprotein Binding Scaffold Protein Binding
	Biological Process	Retina Homeostasis Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Negative Regulation Of Protein Kinase Activity Response To Unfolded Protein Response To Virus Regulation Of Autophagy Viral Process Positive Regulation Of Interleukin-1 Beta Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MRNA Stability Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Chaperone-mediated Protein Folding Platelet Aggregation Negative Regulation Of Protein Serine/threonine Kinase Activity Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis	G2/M Transition Of Mitotic Cell Cycle MAPK Cascade Neuron Migration Regulation Of Heart Rate By Hormone Protein Targeting Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Substantia Nigra Development Hippocampus Development Cerebral Cortex Development Protein Localization To Nucleus Cellular Response To Heat Hippo Signaling Intracellular Signal Transduction Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Export From Nucleus Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Membrane Repolarization Membrane Organization Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Ciliary Basal Body-plasma Membrane Docking Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Cellular Response To Heat Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Peptidyl-serine Dephosphorylation Negative Regulation Of Calcium Ion Export Across Plasma Membrane
Pathways		VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs
Drugs		Apatorsen Phenethyl Isothiocyanate	Fusicoccin Phenethyl Isothiocyanate
Diseases		Distal hereditary motor neuropathies (dHMN)	Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)	Atrial fibrillation ( 30061737) Reaction time ( 29844566) Schizophrenia ( 28991256 30285260)
Interacting Genes		252 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 ARHGAP28 ARHGEF7 ARIH1 ARMT1 ARRDC5 ATXN10 BAG3 BICDL1 BVES C11orf98 C2orf73 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDC123 CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FAM71D FLNB FXR1 GAPVD1 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HECTD1 HNRNPA2B1 HNRNPD HNRNPF HNRNPU HSP90AB1 HSPA4 HSPA5 HSPB8 HUWE1 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MAPT MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 PPA1 PPM1A PPP2R3C PRKD1 PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM39 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC7A9 SMARCA2 SMARCA4 SMARCD1 SNCA SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SQSTM1 SRP72 STUB1 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TMCO3 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3	141 interacting genes: - ABL1 ACD AKAP13 AKAP9 ANKHD1-EIF4EBP3 ANKZF1 ARHGEF2 ARHGEF28 ATP6V0B ATXN1 BAD BCR BEX3 CALM1 CAP2 CASK CASP3 CDC25A CDC25B CDK11B CDK14 CDK16 CDKN1B CEP131 CEP95 CGNL1 CHAF1A CHST11 DDX54 DISC1 DYRK1A ENKD1 EXO1 FAM13B FAM53C FGF12 FHL1 FTH1 GAPDH GPRIN2 GRAP2 GSTA1 GSTM3 GTF2B HDAC4 HDAC5 HIVEP2 HNRNPC HSF1 HSPB1 IGF1R IL7R ING1 IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNH2 KCNK15 KCNK3 KCNK9 KIAA0232 KIF1C KLC4 KRT18 LCP2 MAGEB4 MAP3K1 MAP3K10 MAP3K2 MAP3K3 MAP3K5 MAPK7 MCM10 MDM4 METAP2 MSL2 MST1R MT-CO2 MYH10 NAF1 NCOR2 NDEL1 NIN PAPOLA PARD3B PCM1 PIMREG PNLIP POT1 PRC1 PRDX6 PRKCG RAF1 RAP1GAP2 RASAL3 RASGRF1 RBIS RBM14 REM1 RGS3 RIN1 RPA2 RPGR SAMSN1 SH3BP4 SLC8A1 SLC8A2 SLC8A3 SMAGP SNCA SNF8 SORBS2 SRC SYN2 TAF7 TAZ TBC1D3F TBP TCEANC TFDP2 TGFB1 TLK1 TNFAIP3 TOP2A TSC1 TSC2 UBE3A USP43 VIM WNK1 WWTR1 YWHAB YWHAG YWHAH YWHAQ YWHAZ ZC3HC1 ZNF839
Entrez ID		3315	7531
HPRD ID		09076	05457
Ensembl ID		ENSG00000106211	ENSG00000108953
Uniprot IDs		P04792 V9HW43	P62258 V9HW98
PDB IDs		2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH	2BR9 3UAL 3UBW 6EIH
Enriched GO Terms of Interacting Partners?
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