XIAP and DNM2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		XIAP	DNM2
Description		X-linked inhibitor of apoptosis	dynamin 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Golgi Membrane Phagocytic Cup Photoreceptor Inner Segment Cell Nucleus Cytoplasm Endosome Golgi Apparatus Trans-Golgi Network Centrosome Cytosol Microtubule Plasma Membrane Clathrin-coated Pit Focal Adhesion Postsynaptic Density Microtubule Cytoskeleton Membrane Lamellipodium Axon Growth Cone Midbody Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Mitochondrial Membrane Ruffle Membrane Protein-containing Complex Dendritic Spine Dendritic Spine Head Synapse Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Presynapse Postsynaptic Endocytic Zone Membrane Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	GTPase Activity Protein Binding GTP Binding Microtubule Binding SH3 Domain Binding Enzyme Binding Protein Kinase Binding D2 Dopamine Receptor Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding Protein-containing Complex Binding WW Domain Binding Nitric-oxide Synthase Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Neuron Apoptotic Process Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Mitochondrial Fission G Protein-coupled Receptor Internalization Ventricular Septum Development Regulation Of Transcription, DNA-templated Golgi To Plasma Membrane Transport Endocytosis Receptor-mediated Endocytosis Phagocytosis Signal Transduction Spermatogenesis Response To Light Stimulus Positive Regulation Of Lamellipodium Assembly Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axon Extension Receptor Internalization Transferrin Transport Regulation Of Rac Protein Signal Transduction Aorta Development Response To Cocaine Positive Regulation Of Apoptotic Process Macropinocytosis Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Organelle Fission Synaptic Vesicle Transport Neuron Projection Morphogenesis Positive Regulation Of Phagocytosis Regulation Of Synapse Structure Or Activity Regulation Of Nitric-oxide Synthase Activity Coronary Vasculature Development Membrane Organization Membrane Fusion Cellular Response To Carbon Monoxide Cellular Response To X-ray Cellular Response To Nitric Oxide Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Non-motile Cilium Assembly Cellular Response To Dopamine Regulation Of Golgi Organization Positive Regulation Of Sodium:potassium-exchanging ATPase Activity Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity	Toll Like Receptor 4 (TLR4) Cascade Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions NOSTRIN mediated eNOS trafficking MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Clathrin-mediated endocytosis NGF-stimulated transcription
Drugs		1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Centronuclear myopathy Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Bipolar disorder ( 31043756) Height ( 25429064) LDL cholesterol ( 21347282)
Interacting Genes		82 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BRCA1 CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 ELAVL1 ERCC3 FAF1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSPA1A HTRA1 HTRA2 IKBKE INPP5D KCNJ6 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MDM2 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 PPIH RAF1 RFC5 RIPK2 RIPK3 RIPK4 SEPTIN4 SERTAD1 SQSTM1 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TLE3 TRAF6 TRIM32 TRIM8 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1	57 interacting genes: AMPH AOC1 AP2A1 APP ATF7IP ATXN3 BIN1 CCDC90B CCR5 CCT7 CDK1 CTTN DDX39B DNM1 DNMT1 DYNC1I1 DYNLL1 EIF3L EPS15 FNBP1L GDF9 GOLGA2 GRAP2 GRB2 HCK HMGB1 ITSN1 ITSN2 KDR MAN1B1 MANEA MPHOSPH6 MPP6 NTAQ1 PDE6G PFN1 PPIB PSTPIP1 PTK2 RHOU RPS2 RWDD2B SH3GL2 SH3GLB1 SHANK1 SHANK2 SNX9 SPRY2 SRC TIAM2 TRIP10 TYK2 VAV1 WBP4 XIAP ZBTB16 ZFAND6
Entrez ID		331	1785
HPRD ID		02094	03852
Ensembl ID		ENSG00000101966	ENSG00000079805
Uniprot IDs		B2R9R2 P98170	P50570 Q8N1K8
PDB IDs		1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI	2YS1
Enriched GO Terms of Interacting Partners?
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