HSPA5 and KRT18

Number of citations of the paper that reports this interaction (PubMedID 9409741)
2

Data Source:
HPRD (in vivo)

		HSPA5	KRT18
Description		heat shock protein family A (Hsp70) member 5	keratin 18
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Ribosome Binding Protein Binding Involved In Protein Folding Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Luteolysis ER Overload Response Response To Unfolded Protein Positive Regulation Of Neuron Projection Development Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cell Migration Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Posttranslational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein Complex Assembly Positive Regulation Of Protein Ubiquitination Cellular Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Drug IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Protein Refolding Cellular Response To Glucose Starvation Response To Cocaine Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Neuron Apoptotic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Calcium Ion Cellular Response To Manganese Ion Cellular Response To CAMP Cellular Response To Interleukin-4 Cellular Response To Gamma Radiation Stress Response To Metal Ion Toxin Transport Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Response To Methamphetamine Hydrochloride Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Cell Cycle Anatomical Structure Morphogenesis Viral Process Keratinization Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion
Pathways		Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Keratinization Formation of the cornified envelope
Drugs		Antihemophilic factor, human recombinant Acetylsalicylic acid Copper
Diseases
GWAS			Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		64 interacting genes: A2M APC APOB BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DNAJC3 DPH1 DPYSL5 EIF2AK3 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HMGB1 HSPB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR MATK METTL21A MTNR1A MTNR1B NDRG1 PARK7 PAWR PCSK7 PRNP PSME3 PTPN11 PTPRF RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SREBF2 STMN1 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBC UBE3A UBQLN4 VHL VWF YWHAB	78 interacting genes: BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KPNA2 KRT15 KRT5 KRT72 KRT8 LDOC1 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TNFRSF1B TRADD TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		3309	3875
HPRD ID		00682	01020
Ensembl ID		ENSG00000044574	ENSG00000111057
Uniprot IDs		P11021 V9HWB4	A0A024RAY2 P05783
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS
Enriched GO Terms of Interacting Partners?
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