HSF1 and GTF2A2

Number of citations of the paper that reports this interaction (PubMedID 11005381)
15

Data Source:
HPRD (in vivo, in vitro)

		HSF1	GTF2A2
Description		heat shock transcription factor 1	general transcription factor IIA subunit 2
Image
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Pronucleus Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Chaperone Complex Ribonucleoprotein Complex	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIA Complex Cell Junction
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Protein Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Embryonic Placenta Development DNA Repair MRNA Processing Defense Response Female Meiotic Nuclear Division Spermatogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation MRNA Transcription Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Viral Process Negative Regulation Of Protein Complex Assembly Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Protein-containing Complex Assembly Cellular Response To Potassium Ion Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Embryonic Process Involved In Female Pregnancy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Positive Regulation Of MRNA Polyadenylation Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Positive Regulation Of Microtubule Binding Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Viral Process SnRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity RNA Polymerase II Preinitiation Complex Assembly
Pathways		Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342)	Macular thickness ( 30535121)
Interacting Genes		50 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 EEF1D ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE	8 interacting genes: GTF2A1 GTF2A1L GTF2E1 HSF1 PTPN11 TAF4 TBP TBPL1
Entrez ID		3297	2958
HPRD ID		00778	02747
Ensembl ID		ENSG00000185122	ENSG00000140307
Uniprot IDs		Q00613	A0A024R5Z5 B2R506 P52657
PDB IDs		2LDU 5D5U 5D5V 5HDG 5HDN	1NVP 5FUR 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 5M4S 6MZM 6O9L
Enriched GO Terms of Interacting Partners?
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