APCS and FCGR3B

Number of citations of the paper that reports this interaction (PubMedID 11359830)
48

Data Source:
HPRD (in vitro)

		APCS	FCGR3B
Description		amyloid P component, serum	Fc fragment of IgG receptor IIIb
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Plasma Membrane Secretory Granule Membrane Anchored Component Of Membrane Extracellular Exosome
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Carbohydrate Binding Identical Protein Binding Virion Binding Unfolded Protein Binding	IgG Binding
	Biological Process	Negative Regulation Of Acute Inflammatory Response Protein Folding Acute-phase Response Complement Activation, Classical Pathway Cellular Protein Metabolic Process Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Negative Regulation Of Monocyte Differentiation Negative Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Chaperone-mediated Protein Complex Assembly Negative Regulation Of Wound Healing Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process	Immune Response Neutrophil Degranulation
Pathways		Amyloid fiber formation	Post-translational modification: synthesis of GPI-anchored proteins Neutrophil degranulation
Drugs		Zinc Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE Copper	Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 28240269) C-reactive protein ( 22939635)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Blood protein levels ( 30072576 29875488) Inflammatory bowel disease ( 28067908 23128233) Limited cutaneous systemic scleroderma ( 29293537) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Systemic lupus erythematosus ( 26502338) Systemic sclerosis (anti-centromere-positive) ( 29293537) Ulcerative colitis ( 28067908)
Interacting Genes		17 interacting genes: C1QA C4BPA CALU COL4A1 COPS5 CRP FCGR1A FCGR2B FCGR3A FCGR3B FN1 GK GOT2 GRB2 HES1 LAMA1 TG	2 interacting genes: APCS IGHG1
Entrez ID		325	2215
HPRD ID		00101	09951
Ensembl ID		ENSG00000132703	ENSG00000162747
Uniprot IDs		P02743 V9HWP0	A0A087WU90 A0A087WZR4 A0A3B3ISU3 M9MML6 O75015
PDB IDs		1GYK 1LGN 1SAC 2A3W 2A3X 2A3Y 2W08 3D5O 3KQR 4AVS 4AVT 4AVV 4AYU	1E4J 1E4K 1FNL 1T83 1T89 6EAQ
Enriched GO Terms of Interacting Partners?
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