HOXA1 and DUSP22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HOXA1	DUSP22
Description		homeobox A1	dual specificity phosphatase 22
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Nucleus Cytoplasm Cytosol Plasma Membrane Filamentous Actin Leading Edge Of Lamellipodium
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Sequence-specific DNA Binding	Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine Kinase Binding
	Biological Process	Multicellular Organism Development Sensory Perception Of Sound Optokinetic Behavior Anatomical Structure Morphogenesis Abducens Nerve Formation Outer Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Neurocranium Morphogenesis Inner Ear Development Artery Morphogenesis Regulation Of Behavior Cognition Neuromuscular Process Artery Development Semicircular Canal Formation Cochlea Development Cochlea Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of T Cell Mediated Immunity Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Migration Peptidyl-tyrosine Dephosphorylation Regulation Of Cell Proliferation Positive Regulation Of JNK Cascade Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Negative Regulation Of Focal Adhesion Assembly Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Bosley-Salih-Alorainy syndrome and Athabascan brainstem dysgenesis syndrome
GWAS		Chronic venous disease ( 28374850) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Small cell lung carcinoma ( 28604730) Tonsillectomy ( 27182965 28928442)	Albumin-globulin ratio ( 29403010) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433) Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Male-pattern baldness ( 28196072) Non-albumin protein levels ( 29403010) Serum total protein level ( 29403010) Takayasu arteritis ( 30498034)
Interacting Genes		62 interacting genes: ADAMTSL4 ALG13 BLZF1 CCDC33 CHIC2 CHRD DUSP22 EFEMP2 GATA1 GP9 GRN KDM1A KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE3E LCE4A LGALS13 LPXN MDFI MGAT5B N4BP2L2 NOTCH2NLA PBX2 PIK3R1 PKNOX1 PLSCR1 PRMT6 RBCK1 RBPMS RGS17 RGS20 SDCBP SPRY1 SUV39H1 TBC1D10C TCF3 TRAF1 TRAF2 TRAPPC6A TRIM42 TRIP6	5 interacting genes: HOXA1 MAP2K4 MAP2K7 MAPK14 MAPK8
Entrez ID		3198	56940
HPRD ID		00843	13255
Ensembl ID		ENSG00000105991	ENSG00000112679
Uniprot IDs		P49639	A0A384NLC8 Q9NRW4
PDB IDs			1WRM 4WOH
Enriched GO Terms of Interacting Partners?
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