HMOX2 and INPP5K

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		HMOX2	INPP5K
Description		heme oxygenase 2	inositol polyphosphate-5-phosphatase K
Image			No pdb structure
GO Annotations	Cellular Component	Cell Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Ruffle Nucleus Cytoplasm Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Vasopressin Receptor Activity Protein Binding Inositol Bisphosphate Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Trisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis	In Utero Embryonic Development Negative Regulation Of Protein Phosphorylation Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Protein Kinase Activity Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Glucose Transmembrane Transport Dephosphorylation Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Dephosphorylation Positive Regulation Of Urine Volume Glucose Homeostasis Negative Regulation Of MAP Kinase Activity Negative Regulation By Host Of Viral Transcription Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Calcium Ion Transport Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Protein Targeting To Membrane Ruffle Assembly Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Renal Water Transport
Pathways		Heme degradation Neutrophil degranulation Iron uptake and transport	Synthesis of PIPs at the plasma membrane
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Mean platelet volume ( 27863252)
Interacting Genes		35 interacting genes: A2M APP ATP5F1B BLOC1S2 CEBPZ CEP126 COPS6 CSNK2A1 EEF1G EIF3C GIT1 GPRASP1 HAP1 IMMT INPP5K ITFG1 JADE1 KCNMA1 LMNA LRIF1 MARK3 MED31 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 RBBP4 SETDB1 SHC1 SKA2 SNX5 SNX7 ZFP28 ZNF746	16 interacting genes: ANXA7 ARL6IP1 BDNF CDKN1A CPTP FATE1 FBXO7 HMOX2 HSPB1 KRT31 NCOR2 PFDN1 SMN1 TANK TK1 TTR
Entrez ID		3163	51763
HPRD ID		00783	08489
Ensembl ID		ENSG00000103415	ENSG00000132376
Uniprot IDs		A0A087WT44 B3KSE0 P30519	B7Z4V9 Q9BT40
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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