HMOX1 and TUT1

Number of citations of the paper that reports this interaction (PubMedID 21102410)
26

Data Source:
BioGRID (unspecified method)

		HMOX1	TUT1
Description		heme oxygenase 1	terminal uridylyl transferase 1, U6 snRNA-specific
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Nucleolus Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex Nuclear Speck
	Molecular Function	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Structural Molecule Activity Protein Binding Enzyme Binding Heme Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	RNA Binding MRNA 3'-UTR Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Enzyme Binding Metal Ion Binding RNA Uridylyltransferase Activity
	Biological Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Positive Regulation Of Macroautophagy Negative Regulation Of Macroautophagy Cytokine-mediated Signaling Pathway Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Cellular Response To Heat Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Iron Ion Homeostasis Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Cellular Response To Cisplatin Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Liver Regeneration Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Smooth Muscle Cell Proliferation	MRNA Polyadenylation SnRNA Processing Histone MRNA Catabolic Process Pre-mRNA Cleavage Required For Polyadenylation
Pathways		Heme degradation Interleukin-4 and Interleukin-13 signaling Iron uptake and transport Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		NADH Formic Acid Biliverdine IX Alpha 12-Phenylheme 2-Phenylheme Verdoheme Stannsoporfin 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS		Hippocampal volume in mild cognitive impairment ( 29274321) Obesity-related traits ( 23251661) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: AKT1 ASL BLVRB CPSF1 CREB3 KASH5 LMNA NOS1 PDGFB POR POT1 SNF8 TERF1 TEX33 TUT1 ZNF132	4 interacting genes: CCDC86 HMOX1 IL32 PIN1
Entrez ID		3162	64852
HPRD ID		00782	15226
Ensembl ID		ENSG00000100292	ENSG00000149016
Uniprot IDs		P09601 Q6FH11	A0A0A8K9B1 F5H0R1 Q9H6E5
PDB IDs		1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM 4WD4 5BTQ 6EHA	2E5G 5WU1 5WU2 5WU3 5WU4 5WU5 5WU6
Enriched GO Terms of Interacting Partners?
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