HLCS and DDX52

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HLCS	DDX52
Description		holocarboxylase synthetase	DExD-box helicase 52
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nuclear Lamina Mitochondrion Cytosol Nuclear Matrix	Nucleoplasm Nucleolus Membrane
	Molecular Function	Biotin-[acetyl-CoA-carboxylase] Ligase Activity Biotin-[methylcrotonoyl-CoA-carboxylase] Ligase Activity Biotin-[methylmalonyl-CoA-carboxytransferase] Ligase Activity Biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] Ligase Activity Protein Binding ATP Binding Biotin Binding Biotin-protein Ligase Activity Enzyme Binding Identical Protein Binding	RNA Binding RNA Helicase Activity ATP Binding
	Biological Process	Biotin Metabolic Process Protein Biotinylation Histone Modification Response To Biotin Histone Biotinylation	RRNA Processing Maturation Of SSU-rRNA
Pathways		Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Biotin
Diseases		Holocarboxylase synthetase deficiency
GWAS		Developmental language disorder ( 27016271) Developmental language disorder (linguistic errors) ( 27016271) Intracranial aneurysm ( 29531279) Night sleep phenotypes ( 27126917) Seasonality and depression ( 30217971)	Ovarian cancer ( 23535730)
Interacting Genes		4 interacting genes: ACACB DDX52 POT1 SNX27	5 interacting genes: AP4M1 HLCS MTNR1A PMP22 UTP23
Entrez ID		3141	11056
HPRD ID		08360	09911
Ensembl ID		ENSG00000159267	ENSG00000278053
Uniprot IDs		P50747	B3KM65 Q9Y2R4
PDB IDs			3DKP
Enriched GO Terms of Interacting Partners?
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