HLA-DQA1 and SH3GL2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HLA-DQA1	SH3GL2
Description		major histocompatibility complex, class II, DQ alpha 1	SH3 domain containing GRB2 like 2, endophilin A1
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Golgi Membrane Early Endosome Cytosol Plasma Membrane Cell Junction Clathrin-coated Endocytic Vesicle Membrane Synaptic Vesicle Membrane Neuronal Cell Body Perinuclear Region Of Cytoplasm Basal Dendrite Photoreceptor Ribbon Synapse Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Presynaptic Cytosol
	Molecular Function	Protein Binding MHC Class II Receptor Activity Peptide Antigen Binding	Protein Binding Protein C-terminus Binding Lipid Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Adaptive Immune Response Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II T Cell Receptor Signaling Pathway Interferon-gamma-mediated Signaling Pathway	Negative Regulation Of Protein Phosphorylation Regulation Of Receptor Internalization Signal Transduction Central Nervous System Development Negative Regulation Of Gene Expression Synaptic Vesicle Uncoating Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Neuron Projection Development Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Lipid Tube Assembly Membrane Organization Dendrite Extension Membrane Tubulation Membrane Bending Vesicle Scission Positive Regulation Of Membrane Tubulation Negative Regulation Of Maintenance Of Permeability Of Blood-brain Barrier Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Clathrin-dependent Endocytosis
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling	Retrograde neurotrophin signalling Retrograde neurotrophin signalling EGFR downregulation MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases		Type I diabetes mellitus Dilated cardiomyopathy (DCM) Graves' disease Systemic lupus erythematosus Hashimoto's thyroiditis
GWAS		Adult asthma ( 30578877) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757) Asthma ( 31361310 30929738 27182965 31619474 29273806 23181788) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma (time to onset) ( 27130862) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autism spectrum disorder or schizophrenia ( 28540026) Autoimmune hepatitis in primary sclerosing cholangitis ( 28779025) Autoimmune hepatitis type-1 ( 24768677) Basal cell carcinoma ( 31174203) Blood protein levels ( 29875488) Body mass index ( 28892062) C-reactive protein levels ( 30388399) Celiac disease ( 20190752 17558408) Cervical cancer ( 23482656 28806749) Childhood ear infection ( 27182965 28928442) Childhood steroid-sensitive nephrotic syndrome ( 31263063 29903748) Chronic hepatitis C infection ( 24376798) Chronic lymphocytic leukemia ( 21131588) Chronic rhinosinusitis ( 30643255) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Creatinine levels ( 29403010) Crohn's disease ( 23850713 26891255 23266558) Cutaneous lupus erythematosus ( 25827949) Drug-induced liver injury (flucloxacillin) ( 30661239) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262 29868224) Epstein Barr virus nuclear antigen 1 IgG seropositivity ( 29868224) Epstein-Barr virus immune response (multivariate analysis) ( 29868224) Estimated glomerular filtration rate ( 30604766) Factor VIII levels ( 30586737) Giant cell arteritis ( 28041642 25817017) Glomerular filtration rate ( 29403010) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Hematocrit ( 27863252) Hepatocellular carcinoma ( 22807686) High density lipoprotein cholesterol levels ( 29403010) Hypothyroidism ( 27182965 22493691) Idiopathic membranous nephropathy ( 21323541) IgA nephropathy ( 26028593 25305756) Immune response to anthrax vaccine ( 22658931) Immunoglobulin A vasculitis ( 28698626) Immunoglobulin G index levels in multiple sclerosis ( 25616667) Inflammatory bowel disease ( 28008999 18758464 28067908) Intraocular pressure ( 29785010) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Late-onset myasthenia gravis ( 26562150) Leishmaniasis (visceral) ( 23291585) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lymphocyte counts ( 29403010) Lymphoma ( 23349640) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Membranous nephropathy ( 27333618) Mixed cryoglobulinemia vasculitis in chronic hepatitis C infection ( 25030430) Multiple sclerosis (OCB status) ( 23472185) Myasthenia gravis ( 25643325) Myositis ( 26291516) Nasal polyps ( 30643255) Nephropathy ( 21399633) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Oligoclonal band status in multiple sclerosis ( 25616667) Parental lifespan ( 29030599) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Parkinson's disease ( 27182965 28892059) Peanut allergy ( 25710614) PEG-asparaginase hypersensitivity without enzyme activity in childhood acute lymphoblastic leukaemia ( 30450575) Plantar warts ( 28928442) Pneumonia ( 28928442) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Prostate cancer ( 23535732) Red blood cell count ( 27863252) Response to hepatitis B vaccine ( 29534301) Response to interferon beta therapy ( 21502966) Rheumatoid arthritis ( 18668548 23918589) Rheumatoid arthritis (ACPA-negative) ( 24532677) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Scarlet fever ( 28928442) Schizophrenia ( 23212062 19571809) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Shingles ( 28928442) SjÃ¶gren's syndrome ( 24097066 24097067 28076899) Small cell lung carcinoma ( 28604730) Squamous cell carcinoma ( 31174203 26829030) Squamous cell lung carcinoma ( 28604730) Strep throat ( 28928442) Systemic lupus erythematosus ( 24871463 26606652 26316170 18204098 21408207) Systemic sclerosis ( 21779181) Takayasu arteritis ( 25604533) Tonsillectomy ( 28928442) Total bilirubin levels ( 29403010) Tuberculosis ( 28928442) Type 2 diabetes ( 28566273) Ulcerative colitis ( 28008999 24837172 28067908 26278503 23128233 21297633 19122664 23511034) Urate levels ( 31578528) Vitiligo ( 20410501 27723757) Vogt-Koyanagi-Harada syndrome ( 25108386)	Cerebral cortical growth ( 29682794) Cognitive performance ( 19734545) FEV1 ( 30804560) Heart failure ( 20445134) Lung function (FVC) ( 30804560) Midgestational circulating levels of PBDEs ( 28235828) Multiple sclerosis ( 19010793) Myopia ( 27182965) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pursuit maintenance gain ( 29064472) Small cell lung carcinoma ( 28604730) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: APLP1 BRD2 CD74 CDK7 HLA-DQB1 IKBKG LRIF1 SH3GL2 TLE1 UNC119	51 interacting genes: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 FBXO32 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL3 SH3KBP1 SLC17A7 SYNJ1 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		3117	6456
HPRD ID		06765	05125
Ensembl ID		ENSG00000196735	ENSG00000107295
Uniprot IDs		A0A173ADG5 P01909 Q8MH44	Q7Z376 Q99962
PDB IDs		1JK8 1NBN 1S9V 1UVQ 2NNA 3PL6 4GG6 4OZF 4OZG 4OZH 4OZI 5KSA 5KSB 5KSU 5KSV 6MFF 6MFG	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?
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