HLA-B and STAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HLA-B	STAT1
Description		major histocompatibility complex, class I, B	signal transducer and activator of transcription 1
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Recycling Endosome Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Axon Dendrite Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Peptide Antigen Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Protein Binding Enzyme Binding CCR5 Chemokine Receptor Binding Histone Acetyltransferase Binding Nuclear Hormone Receptor Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin-like Protein Ligase Binding Cadherin Binding Protein Phosphatase 2A Binding Repressing Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Anergy Defense Response Immune Response Viral Process Detection Of Bacterium Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Protection From Natural Killer Cell Mediated Cytotoxicity Neutrophil Degranulation Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Dendritic Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Defense Response Positive Regulation Of Transcription Of Notch Receptor Target JAK-STAT Cascade Response To Nutrient Blood Circulation Response To Mechanical Stimulus Macrophage Derived Foam Cell Differentiation Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-alpha Production Cellular Response To Insulin Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Interferon-beta Cellular Response To Interferon-beta Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Hydrogen Peroxide Regulation Of Apoptotic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Peptide Hormone Endothelial Cell Migration Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Defense Response To Virus Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Renal Tubule Development Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Organic Cyclic Compound Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Metanephric Mesenchymal Cell Differentiation Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Pathways		ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling
Drugs
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Ankylosing spondylitis ( 21743469 30946743) Anti-thyroid drug induced agranulocytosis ( 27157822) Asthma ( 30929738 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738 31619474) Asthma and major depressive disorder ( 31619474) Atopic dermatitis ( 25574825) Autism spectrum disorder or schizophrenia ( 28540026) Basal cell carcinoma ( 27539887) Behcet's disease ( 27548383) Beta-2 microglubulin plasma levels ( 23417110) Blood protein levels ( 29875488 28240269) Body fat percentage variance ( 31453325) Carbamazepine-induced reaction with eosinophilia and systemic symptoms ( 31066027) Cardiometabolic and hematological traits ( 27668658) CD4:CD8 lymphocyte ratio ( 20045101) CD8-positive T-lymphocyte count ( 20045101) Cervical cancer ( 23482656 28806749) Change in intraocular pressure in response to steroid treatment (triamcinolone acetonide) ( 25813999) Chickenpox ( 28928442) Clozapine-induced agranulocytosis ( 25187353) Cold sores ( 28928442) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 26891255) Diastolic blood pressure ( 25249183) Diffuse large B cell lymphoma ( 25261932) Drug-induced liver injury (flucloxacillin) ( 19483685 30661239) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 27863252) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Estimated glomerular filtration rate in diabetes ( 31451708) Frontal fibrosing alopecia ( 30850646) Gastroesophageal reflux disease ( 31527586) Giant cell arteritis ( 28041642) Graves' disease ( 21841780) Height ( 19343178 23563607 31562340) HIV-1 control ( 21051598 20041166) HIV-1 susceptibility ( 23935489) HIV-1 viral setpoint ( 20205591 26039976) Hypothyroidism ( 22493691) IgA nephropathy ( 26028593) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer in ever smokers ( 28604730) Marginal zone lymphoma ( 25569183) Mean corpuscular hemoglobin ( 27863252) Mean platelet volume ( 27863252) Medication use (salicylic acid and derivatives) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 22190364 19525953) Myositis ( 26291516) Nasal polyps ( 30643255) Nasopharyngeal carcinoma ( 20512145) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Neutrophil count ( 29403010) Nevirapine-induced hypersensitivity in HIV ( 28062682) Non-albumin protein levels ( 29403010) Peripheral artery disease ( 31285632) Plantar warts ( 28928442) Platelet count ( 22139419 27863252) Plateletcrit ( 27863252) Pneumonia ( 28928442) Pre-treatment viral load in HIV-1 infection ( 31219150) Primary sclerosing cholangitis ( 23603763) Proliferative diabetic retinopathy ( 31482010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis (ACPA-negative) ( 24532677) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Serum albumin level ( 29403010) Setpoint viral load in HIV-1 infection ( 26553974) Severe aplastic anemia ( 32004448) Shingles ( 30298529 25297839 28928442) Small cell lung carcinoma ( 28604730) Strep throat ( 28928442) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 26606652 28714469) Systolic blood pressure ( 25249183) Takayasu arteritis ( 25604533 30498034 23830517) Tonsillectomy ( 28928442) Trichloroethylene-induced hypersensitivity syndrome ( 26190474) Tuberculosis ( 28928442) Type 2 diabetes ( 25102180) Ulcerative colitis ( 28067908) Visceral adipose tissue adjusted for BMI ( 22589738) Vitiligo ( 20526339) White blood cell count ( 25096241 29403010 21738480) White blood cell count (basophil) ( 27863252)	Birth weight ( 31043758) Height ( 31562340) Inflammatory bowel disease ( 23128233) JT interval (sulfonylurea treatment interaction) ( 27958378) Limited cutaneous systemic scleroderma ( 29293537) Lung cancer (SNP x SNP interaction) ( 24325914) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Primary biliary cholangitis ( 28425483 26394269) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 26316170) Systemic sclerosis ( 29293537)
Interacting Genes		16 interacting genes: ARHGEF4 ATF7IP B2M CD8A CSF1 KIR3DL1 KIR3DS1 KLRD1 LILRB1 LILRB2 MAGEA1 SRC STAT1 TRA TRB TRIB3	107 interacting genes: ACTN4 ADRA1B AKT1 ATF3 BMX BRCA1 CAMK2D CAMK2G CASP3 CASP7 CCR1 CCR5 CREBBP CSE1L CSF2RB CXCR4 DCTN1 DDB1 DDX6 DOT1L DUSP2 DUSP3 E2F1 EGFR EIF1AD EIF2AK2 ELP2 EP300 FADD FANCC FGFR3 FGFR4 FLT1 FOS FTH1 FYN GFAP GTF2I HADH HLA-B HSF1 HSP90AB1 HSPA8 IFNAR2 IFNGR1 IL27RA IL2RB IL2RG IRF1 IRF2 IRF9 JAK1 JAK2 JUN KDR KIT KPNA1 KPNA6 LCK LMO2 LZTR1 MAPK14 MAVS MCM3 MCM5 MDK MT-ND4L NMI NOMO1 NOMO2 OTUD4 PDGFRA PDGFRB PIAS1 PIK3CA POR PRKCD PRMT1 PRMT3 PTK2 PTPN11 PTPN2 RAC1 RACK1 RELA RPS6KA5 RXRA SHANK1 SPTAN1 SPTB SPTBN1 SRC STAT2 STAT3 STAT4 STAT5A STAT5B SUMO4 SYK TNFRSF1A TNFRSF1B TRADD TYK2 UBE2I VDR XPO1 ZNF467
Entrez ID		3106	6772
HPRD ID		00828	02777
Ensembl ID		ENSG00000234745	ENSG00000115415
Uniprot IDs		E5FQ95 P01889	P42224
PDB IDs		1A1M 1A1N 1A1O 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1CG9 1E27 1E28 1HSA 1JGD 1JGE 1K5N 1M05 1M6O 1MI5 1N2R 1OF2 1OGT 1SYS 1SYV 1UXS 1UXW 1W0V 1W0W 1XH3 1XR8 1XR9 1ZHK 1ZHL 1ZSD 2A83 2AK4 2AXF 2AXG 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2H6P 2HJL 2NW3 2NX5 2RFX 2YPK 2YPL 3B3I 3B6S 3BP4 3BP7 3BW9 3BWA 3C9N 3CZF 3D18 3DTX 3DX6 3DX7 3DX8 3DXA 3FFC 3HCV 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LV3 3MV7 3MV8 3MV9 3SJV 3SKM 3SKO 3SPV 3UPR 3VCL 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3W39 3WUW 3X11 3X12 3X13 3X14 4G8G 4G8I 4G9D 4G9F 4JQV 4JQX 4LCY 4LNR 4MJI 4O2C 4O2E 4O2F 4PR5 4PRN 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4XXC 5B38 5B39 5DEF 5DEG 5EO0 5EO1 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5T6W 5T6X 5T6Y 5T6Z 5T70 5TXS 5U98 5V5L 5V5M 5VUD 5VUE 5VUF 5VWD 5VWF 5VWH 5VWJ 5VZ5 5WMN 5WMO 5WMP 5WMQ 5WMR 5XOS 5XOT 6AT5 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6D29 6D2B 6D2R 6D2T 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6P23 6P27 6P2C 6P2F 6P2S 6PYL 6PYV 6PYW 6PZ5	1BF5 1YVL 2KA6 3WWT
Enriched GO Terms of Interacting Partners?
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