HFE and B2M

Number of citations of the paper that reports this interaction (PubMedID 10791995)
54

Data Source:
HPRD (in vitro)

		HFE	B2M
Description		homeostatic iron regulator	beta-2-microglobulin
Image
GO Annotations	Cellular Component	Extracellular Space Cell Nucleoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cytoplasmic Vesicle MHC Class I Protein Complex Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Terminal Web HFE-transferrin Receptor Complex	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion External Side Of Plasma Membrane ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane Early Endosome Lumen Specific Granule Lumen MHC Class I Protein Complex MHC Class I Peptide Loading Complex Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Lumen HFE-transferrin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-2-microglobulin Binding Co-receptor Binding Peptide Antigen Binding Transferrin Receptor Binding	Protein Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Negative Regulation Of T Cell Antigen Processing And Presentation Negative Regulation Of T Cell Cytokine Production Cellular Iron Ion Homeostasis Acute-phase Response Female Pregnancy Response To Iron Ion Cellular Response To Iron Ion Starvation Positive Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Antigen Processing And Presentation BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Transport Regulation Of Iron Ion Transport Hormone Biosynthetic Process Positive Regulation Of Receptor-mediated Endocytosis Iron Ion Homeostasis Multicellular Organismal Iron Ion Homeostasis Protein-containing Complex Assembly Cellular Response To Iron Ion Positive Regulation Of Peptide Hormone Secretion Liver Regeneration Iron Ion Import Across Plasma Membrane Negative Regulation Of Receptor Binding Positive Regulation Of Receptor Binding Negative Regulation Of Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Ferrous Iron Binding Positive Regulation Of Transferrin Receptor Binding Response To Iron Ion Starvation Regulation Of Protein Localization To Cell Surface Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Signaling Receptor Activity Positive Regulation Of Signaling Receptor Activity Negative Regulation Of CD8-positive, Alpha-beta T Cell Activation	Retina Homeostasis Positive Regulation Of T Cell Mediated Cytotoxicity Response To Molecule Of Bacterial Origin Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Exogenous Protein Antigen Via MHC Class Ib, TAP-dependent Positive Regulation Of T Cell Cytokine Production Iron Ion Transport Learning Or Memory Negative Regulation Of Neuron Projection Development Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Positive Regulation Of Protein Binding T Cell Differentiation In Thymus Regulation Of Iron Ion Transport Protein Refolding Neutrophil Degranulation Cellular Protein Metabolic Process Innate Immune Response Regulation Of Erythrocyte Differentiation Response To Cadmium Ion Positive Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Epithelial Cell Proliferation Regulation Of Defense Response To Virus By Virus Negative Regulation Of Neurogenesis Regulation Of Immune Response Protein Homotetramerization Iron Ion Homeostasis Interferon-gamma-mediated Signaling Pathway Cellular Response To Iron Ion Cellular Response To Iron(III) Ion Cellular Response To Nicotine Modulation Of Age-related Behavioral Decline Negative Regulation Of Receptor Binding Positive Regulation Of Receptor Binding Positive Regulation Of Ferrous Iron Binding Positive Regulation Of Transferrin Receptor Binding Amyloid Fibril Formation Positive Regulation Of Cellular Senescence Negative Regulation Of Forebrain Neuron Differentiation
Pathways		Transferrin endocytosis and recycling	ER-Phagosome pathway ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs			Doxycycline 3-Indolebutyric Acid N-Formylmethionine Copper
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Alcohol consumption (transferrin glycosylation) ( 21665994) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 21909110) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 24097068 20686565) Diastolic blood pressure ( 27841878 21909115 28739976 27618447 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Feeling guilty ( 29500382) Glycated hemoglobin levels ( 20858683 28898252) Hematocrit ( 27863252 28017375 19862010) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 19820698 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 28017375) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 21909115) Intelligence (MTAG) ( 29326435) Iron status biomarkers ( 25224454 21483845 21149283 21208937 19820699 19084217) Iron status biomarkers (ferritin levels) ( 28334935 25352340) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) LDL cholesterol ( 24097068 20686565) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 28017375) Mean corpuscular hemoglobin concentration ( 29403010 27863252 28017375) Mean corpuscular volume ( 20139978 28017375 19862010) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Number of sexual partners ( 30643258) Osteoarthritis (hip) ( 30374069) Platelet count ( 27863252) Red blood cell count ( 27863252) Red blood cell traits ( 23446634 20927387 23222517) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 30285260) Systolic blood pressure ( 27841878 21909115 28739976 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Worry too long after an embarrassing experience ( 29500382)
Interacting Genes		3 interacting genes: B2M TFR2 TFRC	22 interacting genes: A2M BAG6 CALR CD1A CD1B CD1D CD1E CD8A CRYAB CXCR4 FCGRT GRB2 HFE HLA-A HLA-B HLA-C HLA-E HLA-F HLA-G HSPB2 LILRB1 PRSS23
Entrez ID		3077	567
HPRD ID		01993	00189
Ensembl ID		ENSG00000010704	ENSG00000166710
Uniprot IDs		B4DV50 F8W7W8 Q30201	P61769
PDB IDs		1A6Z 1C42 1DE4	1A1M 1A1N 1A1O 1A6Z 1A9B 1A9E 1AGB 1AGC 1AGD 1AGE 1AGF 1AKJ 1AO7 1B0G 1B0R 1BD2 1C16 1CE6 1CG9 1DE4 1DUY 1DUZ 1E27 1E28 1EEY 1EEZ 1EFX 1EXU 1GZP 1GZQ 1HHG 1HHH 1HHI 1HHJ 1HHK 1HLA 1HSA 1HSB 1I1F 1I1Y 1I4F 1I7R 1I7T 1I7U 1IM3 1IM9 1JF1 1JGD 1JGE 1JHT 1JNJ 1K5N 1KPR 1KTL 1LDS 1LP9 1M05 1M6O 1MHE 1MI5 1N2R 1OF2 1OGA 1OGT 1ONQ 1P7Q 1PY4 1Q94 1QEW 1QLF 1QQD 1QR1 1QRN 1QSE 1QSF 1QVO 1R3H 1S8D 1S9W 1S9X 1S9Y 1SYS 1SYV 1T1W 1T1X 1T1Y 1T1Z 1T20 1T21 1T22 1TMC 1TVB 1TVH 1UQS 1UR7 1UXS 1UXW 1VGK 1W0V 1W0W 1W72 1X7Q 1XH3 1XR8 1XR9 1XZ0 1YDP 1YPZ 1ZHK 1ZHL 1ZS8 1ZSD 1ZT4 1ZVS 2A83 2AK4 2AV1 2AV7 2AXF 2AXG 2BCK 2BNQ 2BNR 2BSR 2BSS 2BST 2BVO 2BVP 2BVQ 2C7U 2CII 2CIK 2CLR 2D31 2D4D 2D4F 2DYP 2E8D 2ESV 2F53 2F54 2F74 2F8O 2FYY 2FZ3 2GIT 2GJ6 2GT9 2GTW 2GTZ 2GUO 2H26 2H6P 2HJK 2HJL 2HLA 2HN7 2J8U 2JCC 2NW3 2NX5 2P5E 2P5W 2PO6 2PYE 2RFX 2UWE 2V2W 2V2X 2VB5 2VLJ 2VLK 2VLL 2VLR 2X4N 2X4O 2X4P 2X4Q 2X4R 2X4S 2X4T 2X4U 2X70 2X89 2XKS 2XKU 2XPG 2YPK 2YPL 2YXF 2Z9T 3AM8 3B3I 3B6S 3BGM 3BH8 3BH9 3BHB 3BO8 3BP4 3BP7 3BVN 3BW9 3BWA 3BXN 3BZE 3BZF 3C9N 3CDG 3CII 3CIQ 3CZF 3D18 3D25 3D2U 3D39 3D3V 3DBX 3DHJ 3DHM 3DTX 3DX6 3DX7 3DX8 3DXA 3EKC 3FFC 3FQN 3FQR 3FQT 3FQU 3FQW 3FQX 3FT2 3FT3 3FT4 3GIV 3GJF 3GSN 3GSO 3GSQ 3GSR 3GSU 3GSV 3GSW 3GSX 3H7B 3H9H 3H9S 3HAE 3HCV 3HG1 3HLA 3HPJ 3HUJ 3I6G 3I6K 3I6L 3IB4 3IXA 3JTS 3KLA 3KPL 3KPM 3KPN 3KPO 3KPP 3KPQ 3KPR 3KPS 3KWW 3KXF 3KYN 3KYO 3L3D 3L3G 3L3I 3L3J 3L3K 3LKN 3LKO 3LKP 3LKQ 3LKR 3LKS 3LN4 3LN5 3LOW 3LOZ 3LV3 3M17 3M1B 3MGO 3MGT 3MR9 3MRB 3MRC 3MRD 3MRE 3MRF 3MRG 3MRH 3MRI 3MRJ 3MRK 3MRL 3MRM 3MRN 3MRO 3MRP 3MRQ 3MRR 3MV7 3MV8 3MV9 3MYJ 3MYZ 3MZT 3NA4 3NFN 3O3A 3O3B 3O3D 3O3E 3O4L 3OV6 3OX8 3OXR 3OXS 3PWJ 3PWL 3PWN 3PWP 3QDA 3QDG 3QDJ 3QDM 3QEQ 3QFD 3QFJ 3QZW 3REW 3RL1 3RL2 3RWJ 3S6C 3SDX 3SJV 3SKM 3SKO 3SPV 3T8X 3TID 3TIE 3TLR 3TM6 3TO2 3TZV 3U0P 3UPR 3UTQ 3UTS 3UTT 3V5D 3V5H 3V5K 3VCL 3VFM 3VFN 3VFO 3VFP 3VFR 3VFS 3VFT 3VFU 3VFV 3VFW 3VH8 3VRI 3VRJ 3VWJ 3VWK 3VXM 3VXN 3VXO 3VXP 3VXR 3VXS 3VXU 3W0W 3W39 3WL9 3WLB 3WUW 3X11 3X12 3X13 3X14 4E0K 4E0L 4E5X 4EN3 4EUP 4F7M 4F7P 4F7T 4FTV 4FXL 4G8G 4G8I 4G9D 4G9F 4GKN 4GKS 4GUP 4HKJ 4HWZ 4HX1 4I48 4I4W 4JFD 4JFE 4JFF 4JFO 4JFP 4JFQ 4JQV 4JQX 4JRX 4JRY 4K71 4K7F 4KDT 4L29 4L3C 4L3E 4L4T 4L4V 4LCW 4LCY 4LHU 4LNR 4M8V 4MJ5 4MJ6 4MJI 4MNQ 4N0F 4N0U 4N8V 4NNX 4NNY 4NO0 4NO2 4NO3 4NO5 4NQC 4NQD 4NQE 4NQV 4NQX 4NT6 4O2C 4O2E 4O2F 4ONO 4PJ5 4PJ7 4PJ8 4PJ9 4PJA 4PJB 4PJC 4PJD 4PJE 4PJF 4PJG 4PJH 4PJI 4PJX 4PR5 4PRA 4PRB 4PRD 4PRE 4PRH 4PRI 4PRN 4PRP 4QOK 4QRP 4QRQ 4QRR 4QRS 4QRT 4QRU 4R9H 4RA3 4RAH 4RMQ 4RMR 4RMS 4RMT 4RMU 4RMV 4RMW 4U1H 4U1I 4U1J 4U1K 4U1L 4U1M 4U1N 4U1S 4U6X 4U6Y 4UQ2 4UQ3 4WC8 4WDI 4WJ5 4WO4 4WU5 4WU7 4WUU 4WW2 4WWK 4X0S 4X6C 4X6D 4X6E 4X6F 4XXC 4Z76 4Z77 4Z78 5B38 5B39 5BJT 5BRZ 5BS0 5BXF 5C07 5C08 5C09 5C0A 5C0B 5C0C 5C0D 5C0E 5C0F 5C0G 5C0I 5C0J 5C9J 5CFH 5CKA 5CKG 5CS7 5CSB 5CSG 5D2L 5D2N 5D5M 5D7I 5D7J 5D7L 5D9S 5DDH 5DEF 5DEG 5E00 5E6I 5E9D 5ENW 5EO0 5EO1 5EOT 5EU3 5EU4 5EU5 5EU6 5EUO 5F1I 5F7D 5F9J 5FA3 5FA4 5FDW 5GR7 5GRD 5GRG 5GSB 5GSD 5GSR 5GSV 5GSX 5HGA 5HGB 5HGD 5HGH 5HHM 5HHN 5HHO 5HHP 5HHQ 5HYJ 5IB1 5IB2 5IB3 5IB4 5IB5 5IEH 5IEK 5IM7 5INC 5IND 5IRO 5ISZ 5IUE 5J1A 5JHD 5JZI 5KNM 5L2J 5L2K 5MEN 5MEO 5MEP 5MEQ 5MER 5N1Y 5N6B 5NHT 5NME 5NMF 5NMG 5NMH 5NMK 5NQ1 5NQ3 5NQK 5OPI 5SWQ 5T6W 5T6X 5T6Y 5T6Z 5T70 5TEZ 5TRZ 5TS1 5TXS 5U16 5U17 5U1R 5U2V 5U6Q 5U72 5U98 5V5L 5V5M 5VGD 5VGE 5VUD 5VUE 5VUF 5VVP 5VWD 5VWF 5VWH 5VWJ 5VZ5 5W1V 5W1W 5W67 5W69 5W6A 5WER 5WHK 5WJL 5WJN 5WKE 5WKF 5WKG 5WKH 5WKI 5WL1 5WMN 5WMO 5WMP 5WMQ 5WMR 5WSH 5WWI 5WWJ 5WWU 5WXC 5WXD 5XOS 5XOT 5XOV 5YXN 5YXU 6AEE 6AM5 6AMT 6AMU 6APN 6AT5 6AT9 6AVF 6AVG 6BJ2 6BJ3 6BJ8 6BXP 6BXQ 6C09 6C15 6C97 6C98 6C99 6CUG 6D29 6D2B 6D2R 6D2T 6D64 6D78 6DKP 6EI2 6ENY 6EQA 6EQB 6EWA 6EWC 6EWO 6FGB 6G3J 6G3K 6GGM 6GH1 6GH4 6GHN 6GK3 6GL1 6ID4 6IEX 6ILM 6J1V 6J1W 6J29 6J2A 6J2E 6J2G 6J2H 6J2I 6J2J 6K60 6K7T 6MPP 6MT3 6MT4 6MT5 6MT6 6MTL 6MTM 6NCA 6O9B 6O9C 6OPD 6P23 6P27 6P2C 6P2F 6P2S 6PTB 6PTE 6PYL 6PYV 6PYW 6PZ5 6Q3K 6Q3S
Enriched GO Terms of Interacting Partners?
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