HCRT and HCRTR1

Number of citations of the paper that reports this interaction (PubMedID 9491897)
945

Data Source:
HPRD (in vivo, in vitro)

		HCRT	HCRTR1
Description		hypocretin neuropeptide precursor	hypocretin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Cell Rough Endoplasmic Reticulum Synaptic Vesicle Cell Junction Secretory Granule Perinuclear Region Of Cytoplasm Postsynapse	Cell Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Neuropeptide Hormone Activity Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Temperature Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Cellular Response To Hormone Stimulus Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Pidolic Acid	Suvorexant
Diseases
GWAS			Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566)
Interacting Genes		3 interacting genes: HCRTR1 HCRTR2 NPFFR2	6 interacting genes: ARRB1 ARRB2 ATP1B1 CNR1 HCRT PABPC4
Entrez ID		3060	3061
HPRD ID		03836	03863
Ensembl ID		ENSG00000161610	ENSG00000121764
Uniprot IDs		O43612	A6NMV7 O43613
PDB IDs		1CQ0 1R02 1UVQ 1WSO	4ZJ8 4ZJC
Enriched GO Terms of Interacting Partners?
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