SLC40A1 and HAMP

Number of citations of the paper that reports this interaction (PubMedID 15514116)
1140

Data Source:
HPRD (in vivo)

		SLC40A1	HAMP
Description		solute carrier family 40 member 1	hepcidin antimicrobial peptide
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Cell Intercalated Disc Apical Cortex
	Molecular Function	Iron Ion Transmembrane Transporter Activity Protein Binding Ferrous Iron Transmembrane Transporter Activity Peptide Hormone Binding Identical Protein Binding	Hormone Activity
	Biological Process	Lymphocyte Homeostasis Endothelium Development Cellular Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Iron Ion Transmembrane Transport Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Spleen Trabecula Formation Multicellular Organismal Iron Ion Homeostasis Divalent Inorganic Cation Transport Ferrous Iron Export Across Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Acute-phase Response Immune Response Signal Transduction Aging Response To Iron Ion Response To Zinc Ion Killing Of Cells Of Other Organism Response To Vitamin A Negative Regulation Of Iron Ion Transmembrane Transport Response To Erythropoietin Defense Response To Bacterium Response To Ethanol Defense Response To Fungus Multicellular Organismal Iron Ion Homeostasis Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To X-ray Liver Regeneration Cellular Response To Bile Acid Negative Regulation Of Intestinal Absorption Response To Iron Ion Starvation
Pathways		Metal ion SLC transporters Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) Defective CP causes aceruloplasminemia (ACERULOP) Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) Iron uptake and transport
Drugs
Diseases		Hemochromatosis (HFE); Juvenile hemochromatosis (JH)	Hemochromatosis (HFE); Juvenile hemochromatosis (JH)
GWAS		Bone fracture in osteoporosis ( 28580392) Iron status biomarkers (ferritin levels) ( 25352340) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Red blood cell count ( 27863252)	Irritable bowel syndrome ( 29673008) Red cell distribution width ( 28957414)
Interacting Genes		2 interacting genes: GOLM1 HAMP	5 interacting genes: CKAP4 EXOSC5 GLP1R SLC40A1 VKORC1
Entrez ID		30061	57817
HPRD ID		05229	05925
Ensembl ID		ENSG00000138449	ENSG00000105697
Uniprot IDs		Q9NP59	P81172
PDB IDs			1M4E 1M4F 2KEF 3H0T 4QAE
Enriched GO Terms of Interacting Partners?
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