GZMB and SRGN

Number of citations of the paper that reports this interaction (PubMedID 12388539)
19

Data Source:
HPRD (in vitro)

		GZMB	SRGN
Description		granzyme B	serglycin
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Nucleus Cytoplasm Mitochondrion Cytosol Membrane	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity	Protein Binding
	Biological Process	Proteolysis Apoptotic Process Granzyme-mediated Apoptotic Signaling Pathway Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway	Platelet Degranulation Granzyme-mediated Apoptotic Signaling Pathway Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Negative Regulation Of Cytokine Secretion Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization
Pathways		NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria	Platelet degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)	Glycemic traits (pregnancy) ( 23903356)
Interacting Genes		27 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 NEK9 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6	13 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB PF4 PSRC1 SGTA UBQLN1 UBQLN4 UBR4
Entrez ID		3002	5552
HPRD ID		00476	01513
Ensembl ID		ENSG00000100453	ENSG00000122862
Uniprot IDs		J3KQ52 P10144 Q67BC3 Q6XGZ4	P10124
PDB IDs		1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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