TBX21 and HOXC11

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TBX21	HOXC11
Description		T-box transcription factor 21	homeobox C11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Neuronal Cell Body	Nuclear Chromatin Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Heart Looping Regulation Of Transcription, DNA-templated Multicellular Organism Development Response To Virus T Cell Differentiation Negative Regulation Of Interleukin-2 Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Cellular Response To Organic Substance Lymphocyte Migration Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of T-helper 17 Cell Lineage Commitment Negative Regulation Of T-helper 2 Cell Cytokine Production	Metanephros Development Organ Induction Endoderm Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Digit Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal Joint Morphogenesis
Pathways
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 31036433) Body mass index ( 26426971 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically inactive individuals ( 28448500) Diverticular disease ( 30177863) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Multiple sclerosis ( 22190364) Simvastatin-induced myopathy ( 31220337)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: EXOC5 HOXC11 ZNF490	13 interacting genes: CD2AP DNMT3L GTF2A1L GTF2H1 HDAC5 HTT IRF4 MEIS1 SMAD3 SOX8 SP1 STAT3 TBX21
Entrez ID		30009	3227
HPRD ID		05355	09275
Ensembl ID		ENSG00000073861	ENSG00000123388
Uniprot IDs		Q9UL17	O43248
PDB IDs
Enriched GO Terms of Interacting Partners?
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