PDZRN4 and RPS6KA1

Number of citations of the paper that reports this interaction (PubMedID 30726710)
1

Data Source:
BioGRID (unspecified method)

		PDZRN4	RPS6KA1
Description		PDZ domain containing ring finger 4	ribosomal protein S6 kinase A1
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process		Protein Phosphorylation Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Growth Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Hepatocyte Proliferation Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Purvalanol A
Diseases
GWAS		Blood cell traits (multivariate analysis) ( 31080455) Blood protein levels ( 23696881) Body mass index ( 28552196 25673413) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Erectile dysfunction ( 30583798) Facial attractiveness (female raters) ( 30946739) Multiple sclerosis ( 19010793) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913) Urate levels in overweight individuals ( 25811787)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Glucose homeostasis traits ( 25524916) Mean corpuscular volume ( 27863252) Rosacea symptom severity ( 29771307) Triglyceride levels ( 30108155)
Interacting Genes		3 interacting genes: LNX1 LNX2 RPS6KA1	86 interacting genes: ARHGEF11 ARHGEF12 ATXN3 BAD CARHSP1 CCT4 CDKN1B CEBPB CFL1 CREB1 CREBBP DDAH2 DEPTOR DLC1 DLG4 EEF1D EEF2K ERBIN ESR1 ETV1 FGFR1 FOS GBP2 GMFB GOPC GORASP1 GORASP2 GRB2 GRID2IP GSK3B HTRA1 L1CAM LIMK2 LNX1 MAGI1 MAGI2 MAGI3 MAPK1 MAPK3 MAPT MAST1 MAST2 METTL1 MITF MPP1 MTOR MXD1 NFKBIA NR4A1 NR4A2 NR4A3 PARD3B PDCD4 PDPK1 PDZD7 PDZK1 PDZRN3 PDZRN4 PHAX POLDIP3 PPM1G PPP1R3A PPP1R9A PTPN3 RPTOR SHANK3 SHROOM2 SLC9A3R2 SNTA1 SNTB1 SNTG2 SNX27 SRF SRSF5 SYK SYNJ2BP TAMALIN TOB2 TP53 TSC2 TTK UBE2T VCP WHRN YBX1 YWHAB
Entrez ID		29951	6195
HPRD ID		15116	03402
Ensembl ID		ENSG00000165966	ENSG00000117676
Uniprot IDs		B4DGD1 Q6ZMN7	Q15418
PDB IDs			2WNT 2Z7Q 2Z7R 2Z7S 3RNY 3TEI 4H3P 4NIF 5CSF 5CSI 5CSJ 5CSN 5N7D 5N7F 5N7G 5V61 5V62
Enriched GO Terms of Interacting Partners?
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