NME7 and NEFL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NME7	NEFL
Description		NME/NM23 family member 7	neurofilament light
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol	Cytoplasm Cytosol Neurofilament Axon Growth Cone Neuromuscular Junction Schaffer Collateral - CA1 Synapse Cholinergic Synapse Postsynaptic Intermediate Filament Cytoskeleton Presynaptic Intermediate Filament Cytoskeleton Axon Cytoplasm
	Molecular Function	Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Protein Binding, Bridging Identical Protein Binding Phospholipase Binding Protein-containing Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton
	Biological Process	Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process	MAPK Cascade Microtubule Cytoskeleton Organization Anterograde Axonal Transport Retrograde Axonal Transport Peripheral Nervous System Axon Regeneration Axonal Transport Of Mitochondrion Spinal Cord Development Hippocampus Development Cerebral Cortex Development Regulation Of Axon Diameter Neurofilament Bundle Assembly Locomotion Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Intermediate Filament Polymerization Or Depolymerization Intermediate Filament Organization Neuron Projection Morphogenesis Positive Regulation Of Axonogenesis Neuromuscular Process Controlling Balance Protein Polymerization Response To Corticosterone Neurofilament Cytoskeleton Organization Synapse Maturation Postsynaptic Intermediate Filament Cytoskeleton Organization Response To Sodium Arsenite Response To Acrylamide Regulation Of NMDA Receptor Activity
Pathways		Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Coronary artery disease ( 29212778) D-dimer levels ( 21502573) Pulse pressure ( 27841878 30578418) QT interval ( 30679814) Systolic blood pressure ( 27841878 30578418) Venous thromboembolism ( 21980494 22672568)	Fear of minor pain ( 28701861) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		28 interacting genes: C1orf189 CCHCR1 CDC42EP2 CEP72 DDX1 FKBP6 FOSL1 GOLGA2 IKZF1 KRT18 LNX1 MAP4K4 MYOT NAB2 NEFL NT5C2 OFD1 REL SHTN1 SYCE1 TCF4 TCHP TNIP1 TRIM27 TUFT1 YWHAQ ZBTB48 ZNF263	43 interacting genes: BRD7 CCDC172 CCDC33 CCNC CDK5RAP2 CEP57L1 CHD3 DES ENKD1 GFAP GOLGA2 GORASP1 GRIN1 HGS KDM1A KIFC3 KLC3 KRT13 KRT15 KRT18 MAP2 MTMR2 MTUS2 MYO5A NDN NEFH NME7 PDE4DIP PIAS4 PKN1 PPP1R16B PPP1R18 PRMT6 SKIL SPTAN1 TERF1 TEX11 TSC1 TXLNB USHBP1 USP2 VIM YWHAG
Entrez ID		29922	4747
HPRD ID		11394	01206
Ensembl ID		ENSG00000143156	ENSG00000277586
Uniprot IDs		A0A024R8Z7 Q9Y5B8	P07196
PDB IDs
Enriched GO Terms of Interacting Partners?
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