CNOT7 and RAD54L2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		CNOT7	RAD54L2
Description		CCR4-NOT transcription complex subunit 7	RAD54 like 2
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Membrane Nuclear Body Nuclear Speck CCR4-NOT Complex CCR4-NOT Core Complex Host Cell PML Body	Nucleus
	Molecular Function	3'-5'-exoribonuclease Activity Transcription Corepressor Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Transcription Factor Binding Metal Ion Binding	DNA Binding DNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Translation Gene Silencing By RNA Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Regulation Of Tyrosine Phosphorylation Of STAT Protein Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Positive Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	DNA Duplex Unwinding
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163)
Interacting Genes		29 interacting genes: APP BTG1 BTG2 BTG3 CDK1 CDK2 CDK4 CDK6 CNOT6 FBXO7 FHL3 FOXC2 HOXD4 IKBKG LSM3 MRFAP1L1 NMI PABPC1 PIAS1 PSMC1 PSMC2 RAD54L2 SCARA3 SH3GLB2 TEX11 TNRC6A TOB1 TOB2 TSG101	20 interacting genes: AR ATN1 ATXN1 ATXN1L CNOT7 IMPDH2 NR3C1 NR5A1 NR5A2 PIAS1 PPARG PSMA3 RBPMS RXRA SIAH1 SQSTM1 SUMO1 SUMO2 TAX1BP1 UBE2I
Entrez ID		29883	23132
HPRD ID		05370	10018
Ensembl ID		ENSG00000198791	ENSG00000164080
Uniprot IDs		Q96IQ6 Q9UIV1	B3KV54 Q9Y4B4
PDB IDs		2D5R 4GMJ
Enriched GO Terms of Interacting Partners?
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