GUCY1B1 and AGAP1

Number of citations of the paper that reports this interaction (PubMedID 15381706)
9

Data Source:
HPRD (in vivo, two hybrid)

		GUCY1B1	AGAP1
Description		guanylate cyclase 1 soluble subunit beta 1	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Guanylate Cyclase Complex, Soluble Presynaptic Active Zone	Nucleus Cytoplasm
	Molecular Function	Guanylate Cyclase Activity Protein Binding GTP Binding Heme Binding Signaling Receptor Activity Metal Ion Binding	GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	CGMP Biosynthetic Process Nitric Oxide Mediated Signal Transduction Blood Circulation CGMP-mediated Signaling Nitric Oxide-cGMP-mediated Signaling Pathway Cellular Response To Nitric Oxide Trans-synaptic Signaling By Nitric Oxide, Modulating Synaptic Transmission	Protein Transport Positive Regulation Of GTPase Activity
Pathways		Nitric oxide stimulates guanylate cyclase Smooth Muscle Contraction
Drugs
Diseases
GWAS			Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		4 interacting genes: AGAP1 APP GUCY1A2 HSP90AA1	12 interacting genes: APP ARF1 ARF6 CDC42 GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA SMN1 SRC TK1
Entrez ID		2983	116987
HPRD ID		00769	16359
Ensembl ID		ENSG00000061918	ENSG00000157985
Uniprot IDs		B7Z685 B7Z6G8 B7Z9H9 D6RC99 E9PCN2 Q02153	B2RZG9 Q9UPQ3 X5D293
PDB IDs		2WZ1 3UVJ 4NI2 5MNW 6JT0 6JT1 6JT2
Enriched GO Terms of Interacting Partners?
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