USP25 and SUMO3

Number of citations of the paper that reports this interaction (PubMedID 18538659)
82

Data Source:
BioGRID (pull down)

		USP25	SUMO3
Description		ubiquitin specific peptidase 25	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding ATPase Binding	Protein Binding Enzyme Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Protein Sumoylation Negative Regulation Of DNA Binding
Pathways		Ub-specific processing proteases	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Delirium ( 29631748)
Interacting Genes		16 interacting genes: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TNKS UBC UBE2I ZNF426	47 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FOS HIPK2 HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1
Entrez ID		29761	6612
HPRD ID		05296	03754
Ensembl ID		ENSG00000155313	ENSG00000184900
Uniprot IDs		Q9UHP3	P55854
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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