GRM3 and PICK1

Number of citations of the paper that reports this interaction (PubMedID 11891216)
43

Data Source:
HPRD (in vivo)

		GRM3	PICK1
Description		glutamate metabotropic receptor 3	protein interacting with PRKCA 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Axon Dendritic Spine Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome
	Molecular Function	Group II Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Calcium Channel Regulator Activity Glutamate Receptor Activity	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs		LY2140023
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 27611488) Autism spectrum disorder or schizophrenia ( 28540026) Brachial circumference ( 22479309) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Feeling worry ( 29500382) Neurociticism ( 29500382) Neuroticism ( 29255261) Schizophrenia ( 28991256 25056061 29483656 30285260) Seborrheic dermatitis ( 29203360) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Body fat percentage ( 26833246)
Interacting Genes		6 interacting genes: CALM1 GRIP1 PICK1 PPM1A SDCBP TAMALIN	47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7
Entrez ID		2913	9463
HPRD ID		03070	16176
Ensembl ID		ENSG00000198822	ENSG00000100151
Uniprot IDs		A4D1D0 Q14832	A0A024R1J5 Q9NRD5
PDB IDs		1S8M 3SM9 4XAR 5CNK 5CNM 6B7H	2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?