UHRF1 and LIG1

Number of citations of the paper that reports this interaction (PubMedID 28803780)
21

Data Source:
BioGRID (pull down, imaging technique)

		UHRF1	LIG1
Description		ubiquitin like with PHD and ring finger domains 1	DNA ligase 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Heterochromatin Nuclear Matrix	Nucleus Nucleoplasm Cytoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Proximal Promoter Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	DNA Ligation Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Anatomical Structure Morphogenesis V(D)J Recombination DNA Ligation Involved In DNA Repair Cell Division DNA Biosynthetic Process Okazaki Fragment Processing Involved In Mitotic DNA Replication
Pathways		DNA methylation	POLB-Dependent Long Patch Base Excision Repair Early Phase of HIV Life Cycle Processive synthesis on the C-strand of the telomere Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER Processive synthesis on the lagging strand
Drugs			Bleomycin
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Birth weight ( 31043758) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		25 interacting genes: DNMT3A ERCC1 ERG FANCD2 H2AC4 H2BC3 H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PARP1 PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2	11 interacting genes: CSNK2A1 DCAF7 EHMT1 EHMT2 HSPB1 INPP1 MRE11 PCNA RGS2 TUBB3 UHRF1
Entrez ID		29128	3978
HPRD ID		06992	00534
Ensembl ID		ENSG00000276043	ENSG00000105486
Uniprot IDs		A0A087WVR3 Q96T88	B4DM52 F5GZ28 P18858
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW	1X9N 5YY9
Enriched GO Terms of Interacting Partners?
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