GRK5 and TACR1

Number of citations of the paper that reports this interaction (PubMedID 12067742)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		GRK5	TACR1
Description		G protein-coupled receptor kinase 5	tachykinin receptor 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane	Cell Plasma Membrane Integral Component Of Plasma Membrane Sperm Flagellum Sperm Head Sperm Midpiece
	Molecular Function	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Detection Of Abiotic Stimulus Response To Pain Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Flagellated Sperm Motility
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Tachykinin receptors bind tachykinins G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Aprepitant Ketamine Vapreotide AV608 GW 597599 CP-122721 R673 SR 140333 Netupitant Vestipitant Vofopitant
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Mean platelet volume ( 27863252) Methadone dose in opioid dependence ( 30060048) Obesity-related traits ( 23251661) Platelet distribution width ( 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)	Brain connectivity ( 23471985) Chronotype ( 30696823) Diisocyanate-induced asthma ( 25918132) Nonunion in individuals with fractures ( 30680360) Pursuit maintenance gain ( 29064472) Seborrheic dermatitis ( 29203360) Sexual dimorphism in anthropometric traits ( 23754948) Weight ( 28552196)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	5 interacting genes: GPRASP1 GRK5 TAC1 TAC3 TAC4
Entrez ID		2869	6869
HPRD ID		02926	01208
Ensembl ID		ENSG00000198873	ENSG00000115353
Uniprot IDs		P34947	P25103
PDB IDs		4TNB 4TND	2KS9 2KSA 2KSB 6E59 6HLL 6HLO 6HLP
Enriched GO Terms of Interacting Partners?
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