DLL1 and MFNG

Number of citations of the paper that reports this interaction (PubMedID 12036964)
47

Data Source:
HPRD (in vivo)

		DLL1	MFNG
Description		delta like canonical Notch ligand 1	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Adherens Junction Apical Plasma Membrane Cytoplasmic Vesicle Membrane Raft	Extracellular Space Integral Component Of Golgi Membrane
	Molecular Function	Notch Binding Calcium Ion Binding Protein Binding Tat Protein Binding Scaffold Protein Binding	Acetylglucosaminyltransferase Activity O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Activity Metal Ion Binding
	Biological Process	Cell Fate Determination Somitogenesis Somite Specification Heart Looping Marginal Zone B Cell Differentiation Type B Pancreatic Cell Development Notch Signaling Pathway Determination Of Left/right Symmetry Compartment Pattern Specification Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Proximal/distal Pattern Formation Astrocyte Development Regulation Of Somitogenesis Spinal Cord Development Cerebellar Molecular Layer Formation Cerebellar Purkinje Cell Layer Structural Organization Hemopoiesis Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Epithelial Cell Differentiation Negative Regulation Of Interleukin-10 Production Negative Regulation Of Glial Cell Apoptotic Process Organ Growth Regulation Of Growth Negative Regulation Of Cell Differentiation Negative Regulation Of Epidermal Cell Differentiation Negative Regulation Of Inner Ear Auditory Receptor Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Lateral Inhibition Skeletal Muscle Tissue Growth Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Tissue Growth Neuron Fate Specification Inner Ear Development Regulation Of Neurogenesis Regulation Of Cell Division Retina Development In Camera-type Eye Retina Morphogenesis In Camera-type Eye Notch Signaling Pathway Involved In Arterial Endothelial Cell Fate Commitment Left/right Axis Specification Nephron Development Proximal Tubule Development Loop Of Henle Development Clathrin-dependent Endocytosis Energy Homeostasis Endothelial Tip Cell Fate Specification Neuronal Stem Cell Population Maintenance Skin Epidermis Development Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Cardiac Muscle Cell Differentiation	Blastocyst Formation Marginal Zone B Cell Differentiation Pattern Specification Process Regulation Of Notch Signaling Pathway Positive Regulation Of Protein Binding Protein O-linked Fucosylation Positive Regulation Of Notch Signaling Pathway
Pathways		Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus MECP2 regulates transcription of neuronal ligands	Pre-NOTCH Processing in Golgi
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Intraocular pressure ( 29785010) Plasma anti-thyroglobulin levels ( 29678681) Type 1 diabetes ( 21980299)
Interacting Genes		10 interacting genes: ADAM10 CCN3 CNKSR3 MAGI2 MFNG NOTCH1 NOTCH2 NOTCH3 POFUT1 PSEN1	4 interacting genes: DLL1 JAG1 NOTCH1 NOTCH2
Entrez ID		28514	4242
HPRD ID		05957	03988
Ensembl ID		ENSG00000198719	ENSG00000100060
Uniprot IDs		A0A384P5C6 O00548	O00587
PDB IDs		4XBM
Enriched GO Terms of Interacting Partners?
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