ZSCAN1 and ASH2L

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		ZSCAN1	ASH2L
Description		zinc finger and SCAN domain containing 1	ASH2 like, histone lysine methyltransferase complex subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways			Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS			Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		38 interacting genes: ANKRD55 APP ASH2L ATXN1 CDC5L CDK6 CNOT6L ERCC3 FXR2 GOPC GTF2E1 GTF2H1 HOPX INSM2 MED21 MED31 MED7 NPAS2 PLRG1 POLR2B POLR2D POLR2E PPARG PPL RFC1 SH2D2A SNW1 SSX3 SSX5 TAF7 TBX20 TIMELESS TRIM31 TTF2 ZKSCAN5 ZNF263 ZNF396 ZNF407	25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		284312	9070
HPRD ID		15897	05309
Ensembl ID		ENSG00000152467	ENSG00000129691
Uniprot IDs		Q8NBB4	B4DPT1 F5H8F7 Q9UBL3
PDB IDs			3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
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