KCTD1 and PRKAA2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KCTD1	PRKAA2
Description		potassium channel tetramerization domain containing 1	protein kinase AMP-activated catalytic subunit alpha 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Centriolar Satellite Intercellular Bridge	Cell Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Cytoplasmic Stress Granule Nuclear Speck Axon Dendrite Neuronal Cell Body
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Identical Protein Binding	Chromatin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity AMP-activated Protein Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Histone Serine Kinase Activity Metal Ion Binding [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity [acetyl-CoA Carboxylase] Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization	Protein Phosphorylation Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Lipid Biosynthetic Process Positive Regulation Of Autophagy Negative Regulation Of Gene Expression Response To Muscle Activity Wnt Signaling Pathway Macroautophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Cellular Response To Nutrient Levels Negative Regulation Of TOR Signaling Cellular Response To Oxidative Stress Histone-serine Phosphorylation Intracellular Signal Transduction Cellular Response To Drug Cellular Response To Glucose Starvation Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Positive Regulation Of Glycolytic Process Rhythmic Process Fatty Acid Homeostasis Regulation Of Stress Granule Assembly Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Calcium Ion Cellular Response To Glucose Stimulus Cellular Response To Prostaglandin E Stimulus Energy Homeostasis Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Cellular Protein Localization Negative Regulation Of Tubulin Deacetylation Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		Negative regulation of activity of TFAP2 (AP-2) family transcription factors	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Acetylsalicylic acid
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Sudden cardiac arrest ( 21658281)	Lymphocyte counts ( 22286170)
Interacting Genes		13 interacting genes: EPM2AIP1 EXOSC1 KCTD15 LMO3 LNX1 NTAQ1 POLR1C PRKAA2 PSMA1 SDCBP TRAPPC2B UBE2I ZBTB25	52 interacting genes: ABI2 ACACA ACACB AIMP2 APPBP2 C19orf47 CCNB1IP1 DNMT1 EEF2K EPM2A FOS GLI1 HAT1 HMBOX1 HNF4A HOMEZ KCTD1 KIF24 KIFC3 KRT31 KRTAP10-3 L3MBTL3 LEP MYOZ1 NECAB2 NONO NOTCH2NLA NRAP NUTM1 PBXIP1 PFKFB2 PRKAB1 PRKAG1 RBBP7 RBPMS RFX6 RPTOR SNW1 STK11 TCF4 TFAP2A TLE5 TMOD1 TRIP6 TSC22D4 UBE2I USHBP1 USP10 VPS52 WWP1 ZBTB8A ZNF397
Entrez ID		284252	5563
HPRD ID		11059	02735
Ensembl ID		ENSG00000134504	ENSG00000162409
Uniprot IDs		A0A024RC45 A0A2U3U043 Q719H9	P54646
PDB IDs		5BXB 5BXD	2H6D 2LTU 2YZA 3AQV 4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6B2E 6BX6
Enriched GO Terms of Interacting Partners?
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