APEX2 and MFHAS1

Number of citations of the paper that reports this interaction (PubMedID 29513927)
4

Data Source:
BioGRID (pull down)

		APEX2	MFHAS1
Description		apurinic/apyrimidinic endodeoxyribonuclease 2	malignant fibrous histiocytoma amplified sequence 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle	Cytoplasm Mitochondrion Lysosome Cytoskeleton
	Molecular Function	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Phosphodiesterase I Activity Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Binding GTP Binding Ubiquitin Protein Ligase Binding Protein Phosphatase 2A Binding
	Biological Process	Base-excision Repair DNA Recombination Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis	Inflammatory Response Erythrocyte Differentiation Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Protein Dephosphorylation Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of P38MAPK Cascade
Pathways
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Adventurousness ( 30643258) Age at first sexual intercourse ( 27089180) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Chronic obstructive pulmonary disease ( 30804561) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Metabolite levels ( 23823483) Mood instability ( 29187730) Neuroticism ( 29255261) Skin aging (microtopography measurement) ( 28502801) Systemic lupus erythematosus ( 28714469) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		15 interacting genes: APP CALCOCO2 CCDC85B DAPK1 EFEMP2 HOOK2 LRRK2 MAP3K1 MFHAS1 NEDD4L NINL PCNA PGR TRAF2 TRIM37	88 interacting genes: ABLIM1 AGFG1 AHCYL1 AHDC1 ANKRD13A ANKRD13D ANKS4B APEX2 AURKB BAG2 CABP4 CALM1 CALML3 CALU CAPRIN1 CBLB CCDC149 CCDC43 CDC42EP3 CEBPZ CEP85 CETN3 CHGB CLK1 COPB2 CRTC2 CUEDC1 CYREN DDI1 DRC3 E2F4 EGLN2 ESRRG ETV5 FGF16 FGFR1 FOXN3 GAK GAS2L3 GPBP1L1 GSDMD GTSF1 HIC2 IFTAP KLHDC4 LIMA1 LIMK1 MAP3K4 MRGBP NEK1 NEK11 PDCL PGRMC2 PJA2 PMM1 POLA2 POLI PPARG PRKAG2 PSME3IP1 RASL11B RCN2 RHBDD1 ROR1 RPAP3 RTKN SELENOS SH2D2A SLC4A1AP SMTNL2 SNAI1 STK25 STN1 STUB1 SUPT4H1 TADA3 TAS2R60 TBC1D22B TOX2 TRAPPC2 TRIM22 TTC27 UBL7 VGLL4 VN1R1 WWTR1 ZFAND5 ZMYM5
Entrez ID		27301	9258
HPRD ID		06442	12010
Ensembl ID		ENSG00000169188	ENSG00000147324
Uniprot IDs		B4DWI9 B7ZA71 E5KN95 Q9UBZ4	Q9Y4C4
PDB IDs
Enriched GO Terms of Interacting Partners?
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