CRCP and CALCRL

Number of citations of the paper that reports this interaction (PubMedID 10903324)
60

Data Source:
HPRD (in vivo)

		CRCP	CALCRL
Description		CGRP receptor component	calcitonin receptor like receptor
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Cell Nucleoplasm RNA Polymerase III Complex Cytosol Plasma Membrane DNA Polymerase III Complex	Cytoplasm Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Adrenomedullin Receptor Complex CGRP Receptor Complex
	Molecular Function	Nucleotide Binding Calcitonin Gene-related Peptide Receptor Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G Protein-coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Adrenomedullin Binding
	Biological Process	Transcription By RNA Polymerase III Transcription Initiation From RNA Polymerase III Promoter Neuropeptide Signaling Pathway Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus	Angiogenesis Calcium Ion Transport Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Protein Transport Receptor Internalization Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus Calcitonin Gene-related Peptide Receptor Signaling Pathway Adrenomedullin Receptor Signaling Pathway
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Olcegepant Telcagepant
Diseases
GWAS		Aortic root size ( 21223598) Estimated glomerular filtration rate ( 31152163)	Body mass index ( 25673413) Coronary artery disease ( 29212778) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Resting heart rate ( 27798624) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		5 interacting genes: CALCRL POLR3H TCF12 VAV2 ZMIZ2	6 interacting genes: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		27297	10203
HPRD ID		12089	11809
Ensembl ID		ENSG00000241258	ENSG00000064989
Uniprot IDs		A0A024RDL0 O75575	D3DPG9 Q16602
PDB IDs			3AQF 3N7P 3N7R 3N7S 4RWF 4RWG 5V6Y 6D1U 6E3Y
Enriched GO Terms of Interacting Partners?
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