GCLC and CCL22

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GCLC	CCL22
Description		glutamate-cysteine ligase catalytic subunit	C-C motif chemokine ligand 22
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Mitochondrion Cytosol Glutamate-cysteine Ligase Complex	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Glutamate-cysteine Ligase Activity ATP Binding Glutamate Binding ADP Binding Protein-containing Complex Binding Coenzyme Binding	Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Cysteine Metabolic Process Glutamate Metabolic Process Glutathione Biosynthetic Process Response To Oxidative Stress Aging Response To Nutrient Response To Heat Response To Xenobiotic Stimulus Response To Hormone Response To Activity L-ascorbic Acid Metabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Human Chorionic Gonadotropin Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Response To Arsenic-containing Substance Response To Cadmium Ion Response To Nitrosative Stress Regulation Of Mitochondrial Depolarization Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Thyroxine Stimulus Regulation Of Blood Vessel Diameter Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Hepatic Stellate Cell Activation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Glutathione synthesis and recycling Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)	Chemokine receptors bind chemokines Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling
Drugs		Glutamic Acid L-Cysteine
Diseases		Anemia due to disorders of glutathione metabolism, including: Glucose-6-phosphate dehydrogenase (G6PD) deficiency; Glutathione peroxidase (GPX) deficiency; Gamma-glutamylcysteine synthetase (GCLC) deficiency; Glutathione synthetase (GSS) deficiency
GWAS		Benign prostatic hyperplasia ( 30988330) Birth weight ( 31043758) Daytime sleep phenotypes ( 27126917) Waist circumference ( 28552196)	Blood protein levels ( 30072576 29875488) Multiple sclerosis ( 24076602) Systemic lupus erythematosus ( 28714469)
Interacting Genes		1 interacting genes: CCL22	7 interacting genes: CCL19 CCR4 CRYAB DPP4 GCLC HERC3 VCAM1
Entrez ID		2729	6367
HPRD ID		06032	04263
Ensembl ID		ENSG00000001084	ENSG00000102962
Uniprot IDs		E1CEI4 P48506 Q14TF0	O00626
PDB IDs
Enriched GO Terms of Interacting Partners?
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