C5AR2 and C4A

Number of citations of the paper that reports this interaction (PubMedID 11773063)
60

Data Source:
HPRD (in vitro)

		C5AR2	C4A
Description		complement component 5a receptor 2	complement C4A (Rodgers blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Basal Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Junction Axon Dendrite Neuronal Cell Body Synapse Extracellular Exosome Blood Microparticle
	Molecular Function	Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity Protein Binding	Complement Component C1q Binding Endopeptidase Inhibitor Activity
	Biological Process	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Negative Regulation Of Tumor Necrosis Factor Production Complement Component C5a Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Neutrophil Chemotaxis Negative Regulation Of Interleukin-6 Secretion Regulation Of Interleukin-8 Secretion	Inflammatory Response Complement Activation Complement Activation, Classical Pathway Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance
Pathways		Peptide ligand-binding receptors Regulation of Complement cascade	Initial triggering of complement Activation of C3 and C5 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Regulation of Complement cascade
Drugs			Immune Globulin Human
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
GWAS			Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Feeling worry ( 29500382) Inflammatory bowel disease ( 28067908) Neurociticism ( 29500382) Neuromyelitis optica ( 29769526) Neuromyelitis optica (AQP4-IgG-positive) ( 29769526) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908)
Interacting Genes		3 interacting genes: C3 C4A C5AR1	6 interacting genes: APC APOA2 C3AR1 C5AR2 CR1 CST3
Entrez ID		27202	720
HPRD ID		17072	00401
Ensembl ID		ENSG00000134830	ENSG00000244731
Uniprot IDs		Q9P296	P0C0L4
PDB IDs			1HZF 4FXG 4FXK 4XAM 5JPM 5JPN 5JTW
Enriched GO Terms of Interacting Partners?
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