DISC1 and MYT1L

Number of citations of the paper that reports this interaction (PubMedID 17043677)
168

Data Source:
BioGRID (two hybrid)

		DISC1	MYT1L
Description		DISC1 scaffold protein	myelin transcription factor 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Endoplasmic Reticulum Centrosome Cytosol Kinesin Complex Microtubule Synaptic Vesicle Postsynaptic Density Cell Junction Dynein Complex Ciliary Basal Body Cell Body Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Central Region Of Growth Cone Ciliary Base	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding Kinesin Binding Protein-containing Complex Binding Molecular Adaptor Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Zinc Ion Binding
	Biological Process	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Cell-matrix Adhesion Positive Regulation Of Neuroblast Proliferation Cell Proliferation In Forebrain Pyramidal Neuron Migration Positive Regulation Of Wnt Signaling Pathway TOR Signaling Negative Regulation Of Protein Binding Positive Regulation Of Axon Extension Mitochondrial Calcium Ion Homeostasis Response To Electrical Stimulus Regulation Of Synaptic Transmission, Glutamatergic Canonical Wnt Signaling Pathway Regulation Of Dendritic Spine Development Protein Localization To Centrosome Regulation Of Synapse Maturation Non-motile Cilium Assembly Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Nervous System Development Neuron Differentiation Neuron Fate Commitment Neuron Fate Specification Neuron Development
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Arterial stiffness index ( 31235810) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Metabolite levels ( 23823483) Neuranatomic and neurocognitive phenotypes ( 21483430) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to antidepressants (symptom improvement) ( 29160301) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536) Waist circumference ( 28552196)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 18839057) Caudate nucleus volume ( 31530798) Cognitive decline rate in late mild cognitive impairment ( 26252872) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Glucose homeostasis traits ( 25524916) Gut microbiota (functional units) ( 27694959) Impulsivity ( 30718321) Impulsivity (motor) ( 30718321) Impulsivity (non-planning) ( 30718321) Inflammatory skin disease ( 25574825) Mitochondrial DNA copy number (white blood cells) ( 30704525) Moderate-to-late spontaneous preterm birth ( 31194736) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Systemic sclerosis ( 30247649) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Type 2 diabetes (age of onset) ( 28060188) Vitamin B levels in ischemic stroke ( 25147783)
Interacting Genes		107 interacting genes: ACTG1 ACTN2 AGTPBP1 AKAP6 ARIH2 ATF4 ATF5 ATF7IP BICD1 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP126 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FBXW7 FEZ1 FRYL GNB1 GNPTAB GPRASP2 GSK3B HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIF3A KIF3C KIFAP3 MACF1 MAP1A MEMO1 MLLT10 MPPED1 MVP MYH7 MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PCNT PCNX4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI RTRAF SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNKS TRAF3IP1 TRIO TSPOAP1 TUBB TUBB2A UTRN XPNPEP1 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365	3 interacting genes: AURKA CDC5L DISC1
Entrez ID		27185	23040
HPRD ID		05553	14797
Ensembl ID		ENSG00000162946	ENSG00000186487
Uniprot IDs		C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5	A0A2R8YF72 A0A3B3IRM3 A0A3B3IRX5 A0A3B3IS14 A0A3B3IS61 A0A3B3ISW5 Q9UL68
PDB IDs		5V4B
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?