VPS4A and VPS4B

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		VPS4A	VPS4B
Description		vacuolar protein sorting 4 homolog A	vacuolar protein sorting 4 homolog B
Image
GO Annotations	Cellular Component	Spindle Pole Cell Nucleus Cytoplasm Lysosome Endosome Early Endosome Late Endosome Vacuolar Membrane Centrosome Cytosol Plasma Membrane Endosome Membrane Midbody Late Endosome Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Flemming Body	Spindle Pole Cell Nucleus Cytoplasm Endosome Centrosome Cytosol Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled Protein-containing Complex Binding	Protein Binding ATP Binding Protein C-terminus Binding ATPase Activity ATPase Activity, Coupled Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process	Actomyosin Contractile Ring Contraction Protein Targeting To Lysosome Vesicle Budding From Membrane Nucleus Organization Nuclear Envelope Organization Vacuole Organization Mitotic Metaphase Plate Congression Abscission Vesicle-mediated Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Nuclear Envelope Reassembly Intracellular Cholesterol Transport Negative Regulation Of Cytokinesis Regulation Of Protein Localization Endosomal Vesicle Fusion Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Mitotic Cytokinesis Checkpoint Cell Division Cytoskeleton-dependent Cytokinesis Late Endosomal Microautophagy Midbody Abscission Vesicle Uncoating Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Release From Host Cell Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Viral Budding Via Host ESCRT Complex Positive Regulation Of Viral Life Cycle ESCRT Complex Disassembly ESCRT III Complex Disassembly	Potassium Ion Transport Nucleus Organization Vacuole Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Viral Release From Host Cell Cholesterol Transport Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Response To Lipid Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Positive Regulation Of Viral Process Regulation Of Viral Process Protein Depolymerization Negative Regulation Of Cell Death Late Endosomal Microautophagy Midbody Abscission Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Positive Regulation Of Centriole Elongation Positive Regulation Of Viral Life Cycle ESCRT III Complex Disassembly
Pathways		Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Sealing of the nuclear envelope (NE) by ESCRT-III	Budding and maturation of HIV virion Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Body mass index ( 26426971) HDL cholesterol ( 30275531) Logical memory (delayed recall) in normal cognition ( 29274321) Total cholesterol levels in HDL ( 29084231)	Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		9 interacting genes: CHMP1A CHMP1B CHMP2A CHMP4A CHMP4B CHMP4C NPC1 RND2 VPS4B	7 interacting genes: CHMP1A CHMP1B CHMP2A CHMP5 HTRA2 VPS4A ZFYVE19
Entrez ID		27183	9525
HPRD ID		11676	15653
Ensembl ID		ENSG00000132612	ENSG00000119541
Uniprot IDs		A0A024R705 Q9UN37	A0A024R2C5 O75351
PDB IDs		1YXR 2JQ9 2K3W	1WR0 1XWI 2CPT 2JQH 2JQK 4U7Y
Enriched GO Terms of Interacting Partners?
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