INVS and HIF1AN

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		INVS	HIF1AN
Description		inversin	hypoxia inducible factor 1 subunit alpha inhibitor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Spindle Microtubule Cilium Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Calmodulin Binding	Notch Binding Iron Ion Binding Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Oxygen Sensor Activity Carboxylic Acid Binding Peptidyl-histidine Dioxygenase Activity Peptidyl-asparagine 3-dioxygenase Activity Protein Homodimerization Activity Cofactor Binding NF-kappaB Binding Ankyrin Repeat Binding Hypoxia-inducible Factor-asparagine Oxygenase Activity
	Biological Process	Multicellular Organism Development Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway	Peptidyl-histidine Hydroxylation Peptidyl-aspartic Acid Hydroxylation Peptidyl-asparagine Hydroxylation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Notch Signaling Pathway Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Vasculogenesis
Pathways			Cellular response to hypoxia
Drugs			D-tartaric acid N-(carboxycarbonyl)-D-phenylalanine
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Macular thickness ( 30535121) Preeclampsia ( 23551011)	Body mass index ( 28892062 25673413) Cerebrospinal fluid t-tau:AB1-42 ratio ( 30153862) Metabolite levels ( 23823483) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303)
Interacting Genes		4 interacting genes: CALM2 HIF1AN NPHP1 ZNF512B	14 interacting genes: ASB13 ASB4 ASB9 FBF1 HDAC1 HDAC2 HDAC3 HIF1A INVS NAA10 SIAH1 TP53BP2 UACA VHL
Entrez ID		27130	55662
HPRD ID		08356	09426
Ensembl ID		ENSG00000119509	ENSG00000166135
Uniprot IDs		A0A024R153 Q2M1I4 Q9Y283	Q9NWT6
PDB IDs			1H2K 1H2L 1H2M 1H2N 1IZ3 1MZE 1MZF 1YCI 2CGN 2CGO 2ILM 2W0X 2WA3 2WA4 2XUM 2Y0I 2YC0 2YDE 3D8C 3KCX 3KCY 3OD4 3P3N 3P3P 4AI8 4B7E 4B7K 4BIO 4JAA 4NR1 4Z1V 4Z2W 5JWK 5JWL 5JWP 5OP6 5OP8 5OPC 6H9J 6HA6 6HC8 6HKP 6HL5 6HL6
Enriched GO Terms of Interacting Partners?
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