GJB3 and ELAVL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GJB3	ELAVL1
Description		gap junction protein beta 3	ELAV like RNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Gap Junction Connexin Complex Integral Component Of Membrane Cell Junction Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Cytoplasmic Stress Granule Membrane Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex
	Molecular Function	Gap Junction Channel Activity	RNA Binding Double-stranded RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding AU-rich Element Binding Protein Kinase Binding MiRNA Binding MRNA 3'-UTR AU-rich Region Binding Protein Homodimerization Activity
	Biological Process	In Utero Embryonic Development Placenta Development Cell Communication Spermatogenesis Skin Development Transmembrane Transport Cellular Response To Retinoic Acid	MRNA Splicing, Via Spliceosome Protein Import Into Nucleus Regulation Of MRNA Stability Positive Regulation Of Translation MRNA Stabilization Protein Homooligomerization Negative Regulation Of Gene Silencing By MiRNA 3'-UTR-mediated MRNA Stabilization Regulation Of Stem Cell Population Maintenance
Pathways		Gap junction assembly	HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
Drugs
Diseases		Erythrokeratodermia variabilis Deafness, autosomal dominant Deafness, autosomal recessive
GWAS		Intraocular pressure ( 30591961) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883)	Blood protein levels ( 28240269)
Interacting Genes		3 interacting genes: CNST ELAVL1 TJP1	37 interacting genes: ANP32A ANP32B APOE C12orf75 CARM1 CELF2 CHEK2 CTNNB1 ERG FAF2 GJB3 HNRNPK HOTAIR IL7R KPNA1 KPNB1 MIRLET7B MIRLET7I NOS3 PAIP2 PLAU PLAUR PRKCA PRKCD PRKCE PSEN2 PTBP2 PTGS2 RBFOX2 SDCBP SET SREK1 TNPO1 TNPO2 VCP VEGFA XIAP
Entrez ID		2707	1994
HPRD ID		04505	16025
Ensembl ID		ENSG00000188910	ENSG00000066044
Uniprot IDs		O75712	Q15717
PDB IDs			3HI9 4ED5 4EGL 4FXV 5SZW 6G2K 6GC5 6GD1 6GD2 6GD3
Enriched GO Terms of Interacting Partners?
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