SIGLEC7 and TRAF4

Number of citations of the paper that reports this interaction (PubMedID 10514511)
44

Data Source:
HPRD (in vivo, in vitro)

		SIGLEC7	TRAF4
Description		sialic acid binding Ig like lectin 7	TNF receptor associated factor 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Cytoplasm Cytoskeleton Plasma Membrane Bicellular Tight Junction Perinuclear Region Of Cytoplasm Plasma Membrane Receptor Complex
	Molecular Function	Carbohydrate Binding Sialic Acid Binding Signaling Receptor Activity	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Identical Protein Binding WW Domain Binding
	Biological Process	Cell Adhesion Regulation Of Immune Response	Apoptotic Process Activation Of NF-kappaB-inducing Kinase Activity Respiratory Gaseous Exchange Respiratory Tube Development Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein K63-linked Ubiquitination
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs		N-acetyl-alpha-D-glucosamine
Diseases
GWAS		Blood protein levels ( 30072576 29875488)
Interacting Genes		4 interacting genes: GRB2 LGALS3BP PTPN11 TRAF4	78 interacting genes: ALKBH4 BAHD1 BANP BCKDK BCL6B BEX3 BYSL CALCOCO2 CBL CBLC CCHCR1 CENPE CHUK DTX3 EXOC7 FAM214B FAM90A1 FAT1 FBXL18 FTH1 GOLGA2 GORASP2 GPRASP1 HGS HOMEZ IRAK1 ISYNA1 KANSL1 KDM1A KRT31 KRT40 LTBR MAGEC2 MAGED1 MAP3K4 MRPL28 NCF1 NGFR NOS1AP NPAS2 NTRK1 PDE4DIP PKD1P1 PLSCR1 PSMC3 QARS1 RBPMS REXO1L6P RNF114 RPS6KB1 SIGLEC7 SMURF1 SMURF2 SORBS2 SPDL1 SUMO1 TARBP2 TBC1D7 TBC1D8 TGFB1I1 TICAM1 TNFRSF4 TP53BP2 TRAF6 TRIM37 TYK2 UBE2D1 UBE2I UBL4A UBL4B USP7 WBP11 WWP1 WWP2 ZNF3 ZNF512B ZNF581 ZNF688
Entrez ID		27036	9618
HPRD ID		05102	03915
Ensembl ID		ENSG00000168995	ENSG00000076604
Uniprot IDs		Q9Y286	A0A024QZ19 A0A024QZ59 Q9BUZ4
PDB IDs		1NKO 1O7S 1O7V 2DF3 2G5R 2HRL	2EOD 2YUC 3ZJB 4K8U 4M4E 5YC1
Enriched GO Terms of Interacting Partners?
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