MLH3 and MSH4

Number of citations of the paper that reports this interaction (PubMedID 12095912)
35

Data Source:
HPRD (in vitro)

		MLH3	MSH4
Description		mutL homolog 3	mutS homolog 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Male Germ Cell Nucleus Nucleus Nucleoplasm Chiasma Mismatch Repair Complex	Nuclear Chromosome Synaptonemal Complex Nucleus Recombination Nodule
	Molecular Function	Chromatin Binding Satellite DNA Binding Protein Binding ATP Binding ATPase Activity Centromeric DNA Binding Mismatched DNA Binding	DNA Binding Protein Binding DNA-dependent ATPase Activity Mismatched DNA Binding
	Biological Process	Mismatch Repair Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiotic Nuclear Division Female Meiosis I Protein Localization	Resolution Of Meiotic Recombination Intermediates Ovarian Follicle Development Mismatch Repair Synapsis Reciprocal Meiotic Recombination Spermatogenesis Female Gamete Generation
Pathways		Meiotic recombination	Meiotic recombination
Drugs
Diseases		Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Inflammatory bowel disease ( 23128233) Mood instability ( 29187730)	Attention function in attention deficit hyperactive disorder ( 26174813) Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)
Interacting Genes		4 interacting genes: AR MLH1 MSH4 ZDHHC17	9 interacting genes: ACADM DMC1 EIF3F MLH1 MLH3 MSH5 RAD51 RPA1 VBP1
Entrez ID		27030	4438
HPRD ID		05094	03658
Ensembl ID		ENSG00000119684	ENSG00000057468
Uniprot IDs		Q2M1Z1 Q9UHC1	O15457
PDB IDs
Enriched GO Terms of Interacting Partners?
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