GIPR and GIP

Number of citations of the paper that reports this interaction (PubMedID 15655707)
13

Data Source:
HPRD (in vivo)

		GIPR	GIP
Description		gastric inhibitory polypeptide receptor	gastric inhibitory polypeptide
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Lumen Neuronal Cell Body
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Gastric Inhibitory Peptide Receptor Activity Peptide Hormone Binding	Hormone Activity Protein Binding
	Biological Process	Desensitization Of G Protein-coupled Receptor Signaling Pathway Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Glucose Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Gastric Inhibitory Peptide Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Response To Axon Injury Regulation Of Insulin Secretion Response To Calcium Ion Response To Fatty Acid	Signal Transduction G Protein-coupled Receptor Signaling Pathway Female Pregnancy Memory Adult Locomotory Behavior Response To Glucose Response To Selenium Ion Response To Acidic PH Positive Regulation Of Glucose Transmembrane Transport Response To Organic Cyclic Compound Sensory Perception Of Pain Endocrine Pancreas Development Positive Regulation Of Insulin Secretion Response To Lipid Exploration Behavior Regulation Of Fatty Acid Biosynthetic Process Response To Drug Response To Starvation Response To Amino Acid Response To Peptide Hormone Positive Regulation Of CAMP-mediated Signaling Response To Axon Injury Regulation Of Insulin Secretion Digestive System Development Long-term Synaptic Potentiation Positive Regulation Of Glucagon Secretion Triglyceride Homeostasis
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 22344219 24861553 31453325 28892062 20935630 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Breast cancer ( 29059683) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) GIP levels in response to oral glucose tolerance test (fasting) ( 29093273) Hemoglobin A1c levels ( 29403010) Hip circumference ( 31453325 25673412) Hip circumference variance ( 31453325) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Mean corpuscular volume ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Obesity ( 23563607) Pulse pressure ( 30224653) Subcutaneous adipose tissue ( 22589738) Systolic blood pressure ( 30578418) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urinary potassium to creatinine ratio ( 30910378) Waist circumference ( 31453325) Waist circumference variance ( 31453325)	Automobile speeding propensity ( 30643258) Coronary artery disease ( 29212778) Coronary heart disease ( 21378990) Household income ( 31844048) Systolic blood pressure ( 30578418) Type 2 diabetes ( 28566273 29358691)
Interacting Genes		2 interacting genes: GIP LNX1	5 interacting genes: ADAMTSL4 GIPR KRTAP10-3 NOTCH2NLA SGTA
Entrez ID		2696	2695
HPRD ID		00670	15925
Ensembl ID		ENSG00000010310	ENSG00000159224
Uniprot IDs		P48546	P09681
PDB IDs		2QKH 4HJ0 6DKJ	1T5Q 2B4N 2L70 2L71 2OBU 2QKH
Enriched GO Terms of Interacting Partners?
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