GHSR and DRD1

Number of citations of the paper that reports this interaction (PubMedID 27129257)
11

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GHSR	DRD1
Description		growth hormone secretagogue receptor	dopamine receptor D1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Neuron Projection Membrane Raft Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse Integral Component Of Synaptic Membrane	Cell Nucleus Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Junction Dendritic Spine Ciliary Membrane Non-motile Cilium Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Growth Hormone Secretagogue Receptor Activity G Protein-coupled Receptor Activity Protein Binding Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gs Adrenergic Receptor Activity Dopamine Neurotransmitter Receptor Activity Protein Binding Dopamine Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Spermatogenesis Learning Or Memory Actin Polymerization Or Depolymerization Adult Feeding Behavior Response To Hormone Hormone-mediated Signaling Pathway Negative Regulation Of Norepinephrine Secretion Growth Hormone Secretion Response To Food Negative Regulation Of Appetite Positive Regulation Of Appetite Response To Follicle-stimulating Hormone Response To Estradiol Negative Regulation Of Interleukin-1 Beta Production Cellular Response To Insulin Stimulus Ghrelin Secretion Positive Regulation Of Multicellular Organism Growth Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Regulation Of Hindgut Contraction Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Insulin Secretion Decidualization Negative Regulation Of Inflammatory Response Regulation Of Synapse Assembly Regulation Of Transmission Of Nerve Impulse Regulation Of Growth Hormone Secretion Response To Growth Hormone Cellular Response To Lipopolysaccharide Response To Dexamethasone Negative Regulation Of Locomotion Involved In Locomotory Behavior Cellular Response To Thyroid Hormone Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Postsynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Positive Regulation Of Small Intestinal Transit Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Eating Behavior Response To Monosodium Glutamate Positive Regulation Of Small Intestine Smooth Muscle Contraction Negative Regulation Of Tumor Necrosis Factor Secretion Regulation Of Gastric Motility Positive Regulation Of Vascular Endothelial Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Negative Regulation Of Macrophage Apoptotic Process	Temperature Homeostasis Conditioned Taste Aversion Behavioral Fear Response Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Response To Amphetamine Protein Import Into Nucleus G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cell-cell Signaling Synapse Assembly Behavior Memory Mating Behavior Grooming Behavior Adult Walking Behavior Visual Learning Positive Regulation Of Gene Expression Astrocyte Development Dopamine Transport Transmission Of Nerve Impulse Neuronal Action Potential Dentate Gyrus Development Striatum Development Cerebral Cortex GABAergic Interneuron Migration Positive Regulation Of Cell Migration Peristalsis Operant Conditioning Regulation Of Dopamine Metabolic Process Vasodilation Dopamine Metabolic Process Response To Drug Maternal Behavior Positive Regulation Of Potassium Ion Transport Histone H3-S10 Phosphorylation Glucose Import Habituation Sensitization Behavioral Response To Cocaine Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Synaptic Transmission, Glutamatergic Prepulse Inhibition Phospholipase C-activating Dopamine Receptor Signaling Pathway Long-term Synaptic Potentiation Long-term Synaptic Depression Cellular Response To Catecholamine Stimulus Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Cellular Response To Dopamine Regulation Of Synaptic Vesicle Exocytosis
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Ulimorelin Macimorelin	Ziprasidone Cabergoline Cabergoline Ropinirole Olanzapine Olanzapine Methylergometrine Clozapine Mirtazapine Thiethylperazine Phenylpropanolamine Loxapine Loxapine Pramipexole Promazine Imipramine Chlorpromazine Chlorpromazine Haloperidol Triflupromazine Amoxapine Cinnarizine Lisuride Fluphenazine Thioridazine Ergotamine Apomorphine Trimipramine Risperidone Propiomazine Fenoldopam Minaprine Perphenazine Flupentixol Dopamine Dopamine Carphenazine Ergoloid mesylate Acetophenazine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Chlorprothixene Paliperidone Methotrimeprazine Propericiazine Acepromazine Pipotiazine Thioproperazine Thiothixene Zuclopenthixol Iloperidone Rotigotine Mianserin Asenapine Quinagolide Tetrahydropalmatine Dihydrexidine
Diseases
GWAS		Chronotype ( 30696823) Cocaine dependence ( 31212010) Height ( 20881960 25282103 25429064 23563607 31562340) Metabolite levels ( 23823483)	Cadmium levels ( 26025379) Chin dimples ( 27182965) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Treatment response for severe sepsis ( 22310353) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		3 interacting genes: CORT DRD1 GHRL	14 interacting genes: ADA ADORA1 CALY CAV2 COPG1 COPG2 DNAJC14 DRD3 EPB41L2 FLNA GHSR GRIN1 HRH3 PRKACA
Entrez ID		2693	1812
HPRD ID		03541	00538
Ensembl ID		ENSG00000121853	ENSG00000184845
Uniprot IDs		Q92847	P21728
PDB IDs			1OZ5
Enriched GO Terms of Interacting Partners?
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