GFRA1 and RET

Number of citations of the paper that reports this interaction (PubMedID 10774729)
70

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GFRA1	RET
Description		GDNF family receptor alpha 1	ret proto-oncogene
Image
GO Annotations	Cellular Component	Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Receptor Complex Extracellular Exosome	Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Axon Dendrite Neuronal Cell Body Receptor Complex Membrane Raft Plasma Membrane Protein Complex
	Molecular Function	Signaling Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding ATP Binding Signaling Receptor Activity
	Biological Process	MAPK Cascade Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	MAPK Cascade Activation Of MAPK Activity Ureteric Bud Development Neural Crest Cell Migration Embryonic Epithelial Tube Formation Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Neuron Cell-cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Posterior Midgut Development Positive Regulation Of Neuron Projection Development Positive Regulation Of Neuron Maturation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Membrane Protein Proteolysis Positive Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Kinase Activity Ureter Maturation Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Response To Drug Neuron Maturation Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Size Positive Regulation Of Transcription, DNA-templated Response To Pain Enteric Nervous System Development Regulation Of Axonogenesis Positive Regulation Of Protein Kinase B Signaling Retina Development In Camera-type Eye Innervation Peyer's Patch Morphogenesis Cellular Response To Retinoic Acid Positive Regulation Of Metanephric Glomerulus Development Lymphocyte Migration Into Lymphoid Organs Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	RAF/MAP kinase cascade RET signaling
Drugs			Sorafenib 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Vandetanib Cabozantinib Regorafenib Ponatinib Amuvatinib
Diseases			Hirschsprung disease (HD) Renal agenesis and Renal adysplasia Thyroid cancer Congenital central hypoventilation syndrome (CCHS)
GWAS		Blood protein levels ( 30072576 29875488) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)	Blood protein levels ( 30072576 29875488 28240269) Cannabis dependence symptom count ( 27028160) Hirschsprung disease ( 19196962 30031151 25310821 29379196 27702942) Smoking behaviour (cigarettes smoked per day) ( 31089300)
Interacting Genes		5 interacting genes: GDNF NCAM1 NRTN RET SOCS3	44 interacting genes: AKAP5 CBL CBLB CRK CTNNB1 DOK1 DOK2 DOK3 DOK4 DOK5 DOK6 DUSP26 ERBB2 FBXO7 FRS2 GAB1 GDNF GFRA1 GRB10 GRB2 GRB7 IKBKG LRRK1 MAPK1 MAPK14 MAPK3 MAPK8 NEDD4 NOTCH2NLA NOTCH3 NRTN PDLIM7 PIK3R1 PLCG1 PRKAR2A PTK2 PTPN11 PTPRF PTPRR SHC1 SHC3 SHC4 SRC STAT3
Entrez ID		2674	5979
HPRD ID		03291	01266
Ensembl ID		ENSG00000151892	ENSG00000165731
Uniprot IDs		B7Z856 P56159	A0A024R7T2 P07949
PDB IDs		6Q2N	1XPD 2IVS 2IVT 2IVU 2IVV 2X2K 2X2L 2X2M 2X2U 4CKI 4CKJ 4UX8 5AMN 5FM2 5FM3 6FEK 6GL7 6NE7 6NEC 6NJA 6Q2J 6Q2N 6Q2O 6Q2R 6Q2S
Enriched GO Terms of Interacting Partners?
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