GFAP and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		GFAP	PIAS2
Description		glial fibrillary acidic protein	protein inhibitor of activated STAT 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Intermediate Filament Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Regulation Of Protein Complex Assembly Intermediate Filament Organization Regulation Of Chaperone-mediated Autophagy	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		Nuclear signaling by ERBB4 Chaperone Mediated Autophagy	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Alexander disease
GWAS		Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		51 interacting genes: AKT1 APP AURKB BIRC2 CAMK2A CDK1 CEP76 CFAP206 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 KRT19 LGALS14 LMO2 MEN1 MOS MYO15B NEFL NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCB1 SRC STAT1 TLE5 TRIM27 TUBGCP4 UBE3A VIM ZC2HC1C	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		2670	9063
HPRD ID		00675	06944
Ensembl ID		ENSG00000131095	ENSG00000078043
Uniprot IDs		A7REI1 P14136	A0A024RC49 O75928 Q2TA77
PDB IDs		6A9P	2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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