MYCBP and CFL1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MYCBP	CFL1
Description		MYC binding protein	cofilin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Extracellular Space Nucleus Cytoplasm Cytosol Cell-cell Junction Focal Adhesion Membrane Nuclear Matrix Lamellipodium Cortical Actin Cytoskeleton Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Protein Binding	Signaling Receptor Binding Protein Binding Actin Filament Binding
	Biological Process	Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Nucleic Acid-templated Transcription	Mitotic Cytokinesis Neural Crest Cell Migration Neural Fold Formation Protein Phosphorylation Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Regulation Of Cell Morphogenesis Establishment Of Cell Polarity Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Interleukin-12-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation By Host Of Viral Process Regulation Of Dendritic Spine Morphogenesis
Pathways			Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Lauryl Dimethylamine-N-Oxide Copper Artenimol
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 28240269) Menopause (age at onset) ( 26414677)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Psoriasis ( 28537254)
Interacting Genes		15 interacting genes: AKAP1 ARHGEF40 CFAP91 CFL1 COPS6 CPNE1 CPNE2 CPNE4 DISP3 GDF9 MYC MYCBPAP PTN SSRP1 UBC	40 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		26292	1072
HPRD ID		08406	03261
Ensembl ID		ENSG00000214114	ENSG00000172757
Uniprot IDs		Q99417	P23528 V9HWI5
PDB IDs		2YY0	1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W
Enriched GO Terms of Interacting Partners?
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